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Joint modelling of repeated measurements and event time: Application to performance traits and survival of lambs bred in sub-humid tropics

  • Rosemary Nguti1, 3Email author,
  • Tomasz Burzykowski2,
  • John Rowlands3,
  • Didier Renard2 and
  • Paul Janssen2
Genetics Selection Evolution200537:175

https://doi.org/10.1186/1297-9686-37-3-175

Received: 9 March 2004

Accepted: 7 October 2004

Published: 15 March 2005

Abstract

We considered the analysis of a study for Dorper, Red Maasai and crossbred lambs born over a period of 6 years at the Diani Estate, Kenya. The study was designed to compare survival and performance traits of genotypes with differing susceptibilities to helminthiasis. The available data include information on time to death and repeated measurements of body weight, packed cell volume (PCV) and faecal egg count (FEC) of the animals. In the paper, we consider joint modelling of the survival time and the repeated measurements. Such an approach allows to account for the possible association between the survival and repeated measurement processes. The advantages and limitations of the joint modelling are discussed and illustrated using the Diani Estate study data.

Keywords

repeated measurements time-to-event joint modelling sheep helminthiasis

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Authors’ Affiliations

(1)
Department of Mathematics, University of Nairobi
(2)
Center for Statistics, Limburgs Universitair Centrum
(3)
International Livestock Research Institute

Copyright

© INRA, EDP Sciences 2005

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