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Table 4 Biological functions affected by inoculation solely

From: Comparative expression profiling of E. coli and S. aureus inoculated primary mammary gland cells sampled from cows with different genetic predispositions for somatic cell score

  E. coli S. aureus
Top 5 categories of biological functions SCS-BTA18-Q SCS-BTA18-q SCS-BTA18-Q
E. coli versus control SCS-BTA18-Q p-values Genes p-values Genes p-values Genes
Cell death 1,08E-13 96 8,30E-05 18 5,00E-05 14
Cell-to-cell signaling and interaction 3,60E-13 51 5,35E-03 12 2,45E-04 7
Hematological system development and function 3,60E-13 53 7,87E-05 14 8,09E-05 8
Immune cell trafficking 3,60E-13 34 8,62E-04 7 8,09E-05 5
Tissue development 3,60E-13 38 6,51E-03 5 3,49E-03 4
  E. coli S. aureus
Top 5 categories of biological functions SCS-BTA18-Q SCS-BTA18-q SCS-BTA18-Q
E. coli versus control SCS-BTA18-q p-values Genes p-values Genes p-values Genes
Hematological system development and function 3,60E-13 53 7,87E-05 14 8,09E-05 8
Hematopoesis 8,87E-07 27 7,87E-05 9 1,03E-04 5
Cell death 1,08E-13 96 8,30E-05 18 5,00E-05 14
Cellular development 1,67E-07 56 9,58E-05 11 1,52E-05 9
Gene expression 3,39E-11 81 1,25E-04 10 1,11E-03 10
  E. coli S. aureus
Top 5 categories of biological functions SCS-BTA18-Q SCS-BTA18-q SCS-BTA18-Q
S. aureus versus control SCS-BTA18-Q p-values Genes p-values Genes p-values Genes
Inflammatory response 4,38E-11 51 3,63E-03 11 8,30E-06 7
Cellular development 1,67E-07 56 9,58E-05 11 1,52E-05 9
Cellular growth and proliferation 9,89E-12 112 5,35E-03 18 1,52E-05 15
Tissue morphology 5,40E-05 13 6,51E-03 2 4,12E-05 3
Cell death 1,08E-13 96 8,30E-05 18 5,00E-05 15
  1. Top 5 biological functions affected between inoculated SCS-BTA18-Q and SCS-BTA18-q cells and respective control cells; the functional category, p-values and the number of genes are shown for E. coli inoculated SCS-BTA18-Q and SCS-BTA18-q cells and S. aureus inoculated SCS-BTA18-Q cells; the categories are ranked by p-values of the SCS-BTA18-Q and SCS-BTA18-q cells, respectively and related p-values and the number of involved genes are shown for the alternative QTL allele and pathogen; for S. aureus inoculated SCS-BTA18-q cells the number of significantly differentially expressed genes was to low to perform a reliable investigation of associated molecular and cellular functions.