Differential mRNA expression of seven genes involved in cholesterol metabolism and transport in the liver of atherosclerosis-susceptible and -resistant Japanese quail strains

Table 4 Liver mRNA expressions ^§ in SUS and RES quail fed regular or cholesterol diets

Gene	Effect	Regular diet		Cholesterol diet
Gene	Effect	RES (N = 13)	SUS (N = 12)	RES (N = 6)	SUS (N = 6)
HMGCR	*P < 0.01	1.059 ± 0.080	0.776 ± 0.080	1.082 ± 0.127	0.946 ± 0.127
FDFT1	*P < 0.04; †P < 0.02	1.220 ± 0.125	0.598 ± 0.125	0.563 ± 0.177	0.529 ± 0.177
DHCR7		1.209 ± 0.157	1.094 ± 0.157	1.012 ± 0.222a	0.673 ± 0.222b
SQLE	†P < 0.01	1.782 ± 0.308	0.392 ± 0.320	0.044 ± 0.453	0.008 ± 0.453
ABCG5	*† P < 0.05	0.914 ± 0.088a	0.566 ± 0.092b	0.959 ± 0.130ab	1.064 ± 0.130a
ABCG8	*P < 0.01; †P < 0.001	1.153 ± 0.163	0.609 ± 0.169	1.856 ± 0.240	1.331 ± 0.240
APAO1	†P < 0.001	0.857 ± 0.097	0.785 ± 0.101	1.382 ± 0.143	1.412 ± 0.143

N = number of individuals measured; total number of individuals = 37; *denotes significant strain effect; †denotes significant diet effect; *†denotes significant strain x diet interaction; ^§all values (± SEM) indicate the gene of interest relative to GAPDH (arbitrary units).

ISSN: 1297-9686