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Figure 2 | Genetics Selection Evolution

Figure 2

From: Protein evolution of Toll-like receptors 4, 5 and 7 within Galloanserae birds

Figure 2

Projection of detected positively selected sites (PAML/FUBAR/PRIME) and evolutionarily non-conservative sites (ConSurf) onto a 3D protein model of chicken GaGaTLR4 ECD. Positively selected sites are highlighted in red, evolutionarily non-conservative sites in blue and functionally important sites known from mammalian studies [38],[48]-[50],[87] in black (only positions lying in close proximity to the selected or non-conservative sites are numbered); GaGaTLR residue numbering has been adopted; selected sites or non-conservative residues located in close proximity to any of the predicted functional sites are indicated by a filled red or blue rectangle, respectively; arrows indicate positively selected sites concurrent with those identified in previous studies (filled green = avian, filled blue = mammalian, filled green with a blue border = avian and mammalian, open blue = site in neighbourhood); position 268 has been identified in mice and humans as a site directly responsible for MD-2 dimerization and LPS binding.

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