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Figure 3 | Genetics Selection Evolution

Figure 3

From: Whole-genome sequencing identifies a homozygous deletion encompassing exons 17 to 23 of the integrin beta 4 gene in a Charolais calf with junctional epidermolysis bullosa

Figure 3

Histopathological features of JEB in Charolais cattle. (A) Large area of sub-epithelial splitting and blistering. (B) Sub-epithelial splitting and blistering, and cleft formation around hair follicles. (C) Vacuolation beneath basal keratinocytes of the epidermis and fibrin deposition on the dermal side of the vacuoles (5-μm section of tissue embedded in paraffin and stained with haematoxylin and eosin). (D) Vacuolation beneath basal keratinocytes of the epidermis and above the periodic acid Schiff (PAS)-positive basement membrane; 5-μm section of tissue embedded in paraffin and stained with PAS.

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