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Figure 4 | Genetics Selection Evolution

Figure 4

From: Whole-genome sequencing identifies a homozygous deletion encompassing exons 17 to 23 of the integrin beta 4 gene in a Charolais calf with junctional epidermolysis bullosa

Figure 4

Identification of the mutation responsible for JEB in Charolais cattle. (A) Genome-wide screening for extended regions of homozygosity in one JEB-affected calf. Blocks of size ≥ 1 Mb are represented in black on each chromosome. (B) IGV snapshot showing the homozygous deletion that includes exons 17 to 23 of ITGB4 in a JEB affected animal (modified based on results from the chromosome walking approach). (C) Details on the wild-type and mutant nucleotide sequences at the border of the deletion. The deleted segment is underlined; a GG doublet located on both sides of the deletion is indicated in bold.

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Genetics Selection Evolution

ISSN: 1297-9686