Genome-wide association study of body weight in Australian Merino sheep reveals an orthologous region on OAR6 to human and bovine genomic regions affecting height and weight

Table 1 SNPs on OAR6 showing significant association with body weight in 1743 Merino sheep

SNP	Position	Adjusted P-value	n0	n1	n2	p	q	v_g	β (kg)
OAR6_41936490.1	37694563	1.15 × 10⁻¹¹	119	706	918	0.271	0.729	6.17	2.116
s17946.1	37164383	3.88 × 10⁻⁰⁹	83	630	1030	0.228	0.772	5.88	−2.132
OAR6_41877997.1	37640732	1.21 × 10⁻⁰⁷	110	650	983	0.250	0.750	6.05	−1.876
OAR6_41003295.1	36819342	1.17 × 10⁻⁰⁶	150	722	871	0.293	0.707	6.50	−1.741
OAR6_42945420.1	38567455	1.56 × 10⁻⁰⁵	22	321	1400	0.105	0.895	6.54	2.28
OAR6_40449774.1	36234302	3.87 × 10⁻⁰⁴	20	378	1345	0.120	0.880	6.62	−2.079
OAR6_41558126.1	37334387	5.45 × 10⁻⁰⁴	79	574	1090	0.210	0.790	6.30	1.686
OAR6_40409402.1	36192023	1.61 × 10⁻⁰³	9	254	1480	0.078	0.922	6.65	2.337
OAR6_40370293.1	36155169	1.65 × 10⁻⁰³	110	641	992	0.247	0.753	6.25	−1.589
OAR6_42247197.1	37987281	1.97 × 10⁻⁰³	60	512	1171	0.181	0.819	6.52	−1.645
OAR6_40724811_X.1	36522166	3.61 × 10⁻⁰³	18	385	1340	0.121	0.879	6.26	−1.914
OAR6_40855809.1	36655091	5.65 × 10⁻⁰³	53	448	1242	0.159	0.841	6.34	1.612
OAR6_41768532.1	37533664	9.01 × 10⁻⁰³	64	521	1158	0.186	0.814	6.46	1.542

Thirteen SNPs on OAR6 reach the genome-wide significance level (adjusted P-value < 0.01). These SNPs span the region between 36.15 and 38.56 Mb. A total of 45 SNPs on the Illumina Ovine SNP50 BeadChip are mapped to this region and 30 were identified as significant for an unadjusted p-value threshold of 0.001. n0, n1, and n2 are the number of individuals with 2, 1 and 0 copies of the minor allele; p is the minor allele frequency and q = 1 – p; Vg indicates the proportion of the genetic variance that is attributable to each SNP estimated by ASReml (note that SNPs are not unlinked and the sum of effects will be overestimated). β is the allele substitution effect. SNP positions are based on the Oar_v3.1 assembly of the ovine genome sequence

ISSN: 1297-9686