Comparison of host genetic factors influencing pig response to infection with two North American isolates of porcine reproductive and respiratory syndrome virus

Table 7 Estimates of genetic correlations of response to infection between PRRSV isolates when excluding the 5 Mb WUR region from the G matrix

Trait	Full (G _−W)			Block diagonal (G _B–W)			Paired block diagonal (G _P–W)
	Heritability		Genet cor.	Heritability		Genet cor.	Heritability		Genet cor.
	NVSL	KS06	Genet cor.	NVSL	KS06	Genet cor.	NVSL	KS06	Genet cor.
VL	0.25 (0.06)	0.49 (0.09)	0.76 (0.22)	0.34 (0.06)	0.49 (0.08)	0.44 (0.26)	0.45 (0.08)	0.49 (0.09)	0.51 (0.24)
WG	0.28 (0.06)	0.30 (0.09)	0.89 (0.29)	0.33 (0.06)	0.31 (0.07)	0.93 (0.35)	0.36 (0.08)	0.38 (0.11)	0.90 (0.32)
TP	0.21 (0.05)	0.20 (0.09)	0.18 (0.34)	0.27 (0.06)	0.28 (0.10)	0.36 (0.37)	0.31 (0.08)	0.29 (0.12)	0.37 (0.37)
PV	0.13 (0.05)	0.40 (0.08)	0.79 (0.34)	0.22 (0.06)	0.39 (0.08)	0.81 (0.37)	0.51 (0.10)	0.55 (0.36)	0.77 (0.36)
Tmax	0.19 (0.05)	0.14 (0.09)	0.80 (0.54)	0.24 (0.06)	0.16 (0.10)	0.90 (0.62)	NE^a	NE	NE
Vmax	0.10 (0.05)	0.23 (0.09)	0.70 (0.53)	0.13 (0.05)	0.21 (0.09)	0.57 (0.70)	0.06 (0.07)	0.22 (0.11)	0.75 (1.03)

WG weight gain (kg), VL viral load (area under the Wood’s curve of log₁₀ serum viremia from 0 to 21 days post infection; viremia * days), TP time to peak viremia (days), PV peak viremia (log₁₀ serum viremia), Tmax time to maximal rate of viremia decay (days), Vmax maximal rate of viremia decay (log₁₀ serum viremia/day)
G _−W = full G-matrix constructed excluding the 5 Mb region containing WUR with all relationships included; G _B−W = block diagonal G-matrix constructed excluding the 5 Mb region containing WUR, with the relationships between animals from different genetic backgrounds set to zero; G _P−W = paired block diagonal G-matrix constructed excluding the 5 Mb region containing WUR, with the relationships between animals from different genetic backgrounds set to zero, and only included trials in which pigs from the same genetic background were infected with both NVSL and KS06
^aNE: were not estimated because the model did not achieve convergence in ASReml

ISSN: 1297-9686