Table 1 Efficiency of turning genetic variation into genetic gain in generations 4, 8, 12, 16, and 20 of future breeding
From: Potential of gene drives with genome editing to increase genetic gain in livestock breeding programs
Editing strategy | Number of edited sires | Efficiency of turning genetic variation into genetic gain (95% CI) | ||||
|---|---|---|---|---|---|---|
Gen 4 | Gen 8 | Gen 12 | Gen 16 | Gen 20 | ||
Selection | 0 | 1.34 (1.24–1.43) | 1.27 (1.21–1.32) | 1.21 (1.16–1.27) | 1.18 (1.14–1.22) | 1.14 (1.10–1.17) |
Genome editing alone | 25 | 2.65 (2.42–2.87) | 2.51 (2.39–2.62) | 2.38 (2.25–2.51) | 2.27 (2.15–2.38) | 2.16 (2.07–2.25) |
With gene drives | 25 | 3.66 (3.34–3.99) | 3.43 (3.26–3.61) | 3.25 (3.14–3.36) | 3.10 (2.98–3.22) | 2.95 (2.85–3.05) |
Genome editing alone | 5 | 2.12 (1.98–2.27) | 1.73 (1.65–1.81) | 1.52 (1.44–1.61) | 1.44 (1.35–1.52) | 1.38 (1.30–1.45) |
With gene drives | 5 | 4.83 (4.29–5.37) | 3.84 (3.59–4.09) | 3.38 (3.10–3.67) | 3.06 (2.83–3.28) | 2.76 (2.59–2.93) |