Skip to main content

Table 3 Regions containing putative lethal recessive haplotypes with an effect on total number born using the S × MGS model

From: Use of haplotypes to identify regions harbouring lethal recessive variants in pigs

Region

Step 1A

Step 1C

Step 2, S × MGS model

\(P (O[ H ] = 0 | E[ H ])\)

\(P (O[ H ] = 0 | S,MGS\;Carriers)\)

P value of MS

\(R\)

Number of SE from the expectation of a lethal recessive effect

Number of SE from no effect

1.1

2.15 × 10 −3

3.37 × 10 −1

6.99 × 10 −5

0.092

1.39

3.95

1.2

1.17 × 10−3

2.89 × 10−1

7.11 × 10−3

0.070

2.13‡

2.68

1.1 and 1.2 †

  

2.07 × 10 −4

0.122

0.09

3.68

6.1

7.84 × 10−4

4.61 × 10−1

3.25 × 10−3

0.103

0.62

2.93

10.1

5.30 × 10−3

4.74 × 10−6

7.69 × 10−3

0.083

1.37

2.65

14.1

1.77 × 10 −3

8.67 × 10 −3

6.28 × 10 −10

0.101

1.45

6.04

14.2

1.50 × 10 −2

1.93 × 10 −2

1.01 × 10 −5

0.084

2.11 ‡

4.36

14.1 and 14.2 †

  

2.97 × 10 −6

0.097

1.33

4.59

  1. Regions containing a putative lethal recessive haplotype are named based on the chromosome and their order along that chromosome, i.e. 6.1 refers to the first region containing a putative lethal recessive haplotype located along chromosome 6. P values are given for the probability of observing no homozygotes within the population given the number expected based on the frequency of the haplotype (\(P (O[ H ] = 0 |E[ H ])\)), the probability of observing no homozygous offspring given the expected number from matings between a carrier sire and a carrier maternal grand sire (\(P\left( {O[ H ] = 0 | S, MGS Carriers} \right)\)) and the significance of mating status (MS) using the S × MGS model. \(R\) is the relative reduction in total number born as a result of matings between two carriers compared to matings between a carrier and a non-carrier. The number of standard errors that \(R\) was from the expectation of a lethal recessive effect and from no effect are given. ‡ indicates a departure from the expectation of a lethal effect. P values are nominal, with the haplotypes that achieve Bonferroni corrected significance (P < 3.25 × 10−4) for MS highlighted in italics. Results arising from the concurrent assessment of two putative lethal recessive haplotypes are denoted by â€