Skip to main content

Table 6 Gene Ontology (GO) functional enrichment with false discovery rate (FDR) < 0.05

From: Within-breed and multi-breed GWAS on imputed whole-genome sequence variants reveal candidate mutations affecting milk protein composition in dairy cattle

 

Pathway ID

Pathway description

Gene count

FDR

Genes

Biological process

GO.1903494

Response to dehydroepiandrosterone

4

1.73e–08

CSN1S1, CSN1S2, CSN2, CSN3

GO.1903496

Response to 11-deoxycorticosterone

4

1.73e–08

CSN1S1, CSN1S2, CSN2, CSN3

GO.0032570

Response to progesterone

4

1.81e–07

CSN1S1, CSN1S2, CSN2, CSN3

GO.0097305

Response to alcohol

5

3.69e–07

ALPL, CSN1S1, CSN1S2, CSN2, CSN3

GO.0032355

Response to estradiol

4

2.34e–06

CSN1S1, CSN1S2, CSN2, CSN3

GO.1901700

Response to oxygen-containing compound

6

9.04e–05

ALPL, CSN1S1, CSN1S2, CSN2, CSN3, PKD2

GO.0014070

Response to organic cyclic compound

5

0.000176

ALPL, CSN1S1, CSN1S2, CSN2, CSN3

GO.0033993

Response to lipid

5

0.000181

ALPL, CSN1S1, CSN1S2, CSN2, CSN3

GO.0009719

Response to endogenous stimulus

5

0.00205

CSN1S1, CSN1S2, CSN2, CSN3, PKD2

GO.0048732

Gland development

3

0.0281

CSN2, CSN3, PKD2

GO.0060416

Response to growth hormone

2

0.0281

CSN1S1, CSN1S2

GO.0007595

Lactation

2

0.0298

CSN2, CSN3

Cellular component

GO.0005796

Golgi lumen

4

1.97e–08

CSN1S1, CSN1S2, CSN2, CSN3

GO.0012505

Endomembrane system

8

0.00253

AGPAT6, CSN1S1, CSN1S2, CSN2, CSN3, DGAT1, MGST1, PKD2

GO.0005576

Extracellular region

7

0.0372

ALPL, CSN1S1, CSN1S2, CSN2, CSN3, PAEP, PKD2

GO.0005789

Endoplasmic reticulum membrane

4

0.0372

AGPAT6, DGAT1, MGST1, PKD2

GO.0042175

Nuclear outer membrane-endoplasmic reticulum membrane network

4

0.0372

AGPAT6, DGAT1, MGST1, PKD2

GO.0044444

Cytoplasmic part

9

0.0372

ABCG2, AGPAT6, CSN1S1, CSN1S2, CSN2, CSN3, DGAT1, MGST1, PKD2

GO.0044446

Intracellular organelle part

9

0.0372

ABCG2, AGPAT6, CSN1S1, CSN1S2, CSN2, CSN3, DGAT1, MGST1, PKD2

Molecular function

GO.0035375

Zymogen binding

2

0.0177

CSN1S2, CSN3