The impact of genome editing on the introduction of monogenic traits in livestock

Table 3 Population parameters after five generations of selection

Method	b ^a₂	Reduced response		Allele frequency^c	\(\overline{F}\) ^d	Number^e	Cumulative benefit^f
Method	b ^a₂	σ _A	Months^b	Allele frequency^c	\(\overline{F}\) ^d	Number^e	Dominant (%)	Recessive (%)
	0	0	0	0.01	0.022	0	2.1	0.0
GS	0.5	− 0.57	− 8.9	0.59	0.024	0	43.6	11.7
	1000	− 1.95	− 30.2	0.96	0.035	0	84.2	62.9
	0	− 0.02	− 0.3	0.66	0.022	10,000	60.6	20.4
GS + GE	0.5	− 0.23	− 3.5	1.00	0.023	7072	84.3	69.4
	1000	− 0.79	− 12.2	1.00	0.028	3912	90.4	79.1

^aIndex weight for the genotype of the monogenic trait
^bMonths of selection response lost for the polygenic trait in generation 5, compared to the genetic level of genomic selection (GS) with b₂ = 0
^cFrequency of the desired allele in generation 5
^dMean inbreeding coefficient in generation 5
^eCumulative number of editing procedures over 5 generations
^fPercentage of animals, cumulative over the 5 generations, with the desired phenotype when the desired allele is either dominant or recessive

ISSN: 1297-9686