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Table 3 Population parameters after five generations of selection

From: The impact of genome editing on the introduction of monogenic traits in livestock

Method b a2 Reduced response Allele frequencyc \(\overline{F}\) d Numbere Cumulative benefitf
σ A Monthsb Dominant (%) Recessive (%)
  0 0 0 0.01 0.022 0 2.1 0.0
GS 0.5 − 0.57 − 8.9 0.59 0.024 0 43.6 11.7
  1000 − 1.95 − 30.2 0.96 0.035 0 84.2 62.9
  0 − 0.02 − 0.3 0.66 0.022 10,000 60.6 20.4
GS + GE 0.5 − 0.23 − 3.5 1.00 0.023 7072 84.3 69.4
  1000 − 0.79 − 12.2 1.00 0.028 3912 90.4 79.1
  1. aIndex weight for the genotype of the monogenic trait
  2. bMonths of selection response lost for the polygenic trait in generation 5, compared to the genetic level of genomic selection (GS) with b2 = 0
  3. cFrequency of the desired allele in generation 5
  4. dMean inbreeding coefficient in generation 5
  5. eCumulative number of editing procedures over 5 generations
  6. fPercentage of animals, cumulative over the 5 generations, with the desired phenotype when the desired allele is either dominant or recessive