Success ratea
|
Monthsb
|
Proceduresc
|
Cumulative benefitd
|
---|
Dominant (%)
|
Recessive (%)
|
---|
1.00
|
0.0
|
7072
|
96.1
|
92.4
|
0.80
|
+ 0.7
|
8184
|
95.5
|
91.0
|
0.60
|
− 2.4
|
9006
|
94.6
|
89.1
|
0.40
|
− 2.1
|
10,418
|
93.2
|
86.8
|
0.20
|
− 5.3
|
12,299
|
90.9
|
83.3
|
0.10
|
− 5.2
|
13,162
|
89.6
|
81.3
|
- Impact of editing success rate under moderate selection intensity for the desired allele combined with genome editing
- aSuccess rate of editing an undesired allele into the desired allele
- bLong-term loss (measured at generation 20) in months of selection response for the polygenic trait, compared to a success rate of 1.00
- cTotal number of editing procedures
- dPercentage of animals with the desired phenotype, cumulative over 20 generations, when the desired allele is either dominant or recessive