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Table 5 Long-term impact of success rate of genome editing

From: The impact of genome editing on the introduction of monogenic traits in livestock

Success ratea Monthsb Proceduresc Cumulative benefitd
Dominant (%) Recessive (%)
1.00 0.0 7072 96.1 92.4
0.80 + 0.7 8184 95.5 91.0
0.60 − 2.4 9006 94.6 89.1
0.40 − 2.1 10,418 93.2 86.8
0.20 − 5.3 12,299 90.9 83.3
0.10 − 5.2 13,162 89.6 81.3
  1. Impact of editing success rate under moderate selection intensity for the desired allele combined with genome editing
  2. aSuccess rate of editing an undesired allele into the desired allele
  3. bLong-term loss (measured at generation 20) in months of selection response for the polygenic trait, compared to a success rate of 1.00
  4. cTotal number of editing procedures
  5. dPercentage of animals with the desired phenotype, cumulative over 20 generations, when the desired allele is either dominant or recessive