Success ratea | Monthsb | Proceduresc | Cumulative benefitd |
---|
Dominant (%) | Recessive (%) |
---|
1.00 | 0.0 | 7072 | 96.1 | 92.4 |
0.80 | + 0.7 | 8184 | 95.5 | 91.0 |
0.60 | − 2.4 | 9006 | 94.6 | 89.1 |
0.40 | − 2.1 | 10,418 | 93.2 | 86.8 |
0.20 | − 5.3 | 12,299 | 90.9 | 83.3 |
0.10 | − 5.2 | 13,162 | 89.6 | 81.3 |
- Impact of editing success rate under moderate selection intensity for the desired allele combined with genome editing
- aSuccess rate of editing an undesired allele into the desired allele
- bLong-term loss (measured at generation 20) in months of selection response for the polygenic trait, compared to a success rate of 1.00
- cTotal number of editing procedures
- dPercentage of animals with the desired phenotype, cumulative over 20 generations, when the desired allele is either dominant or recessive