The impact of genome editing on the introduction of monogenic traits in livestock

Table 5 Long-term impact of success rate of genome editing

Success rate^a	Months^b	Procedures^c	Cumulative benefit^d
Success rate^a	Months^b	Procedures^c	Dominant (%)	Recessive (%)
1.00	0.0	7072	96.1	92.4
0.80	+ 0.7	8184	95.5	91.0
0.60	− 2.4	9006	94.6	89.1
0.40	− 2.1	10,418	93.2	86.8
0.20	− 5.3	12,299	90.9	83.3
0.10	− 5.2	13,162	89.6	81.3

Impact of editing success rate under moderate selection intensity for the desired allele combined with genome editing
^aSuccess rate of editing an undesired allele into the desired allele
^bLong-term loss (measured at generation 20) in months of selection response for the polygenic trait, compared to a success rate of 1.00
^cTotal number of editing procedures
^dPercentage of animals with the desired phenotype, cumulative over 20 generations, when the desired allele is either dominant or recessive

ISSN: 1297-9686