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Table 5 Long-term impact of success rate of genome editing

From: The impact of genome editing on the introduction of monogenic traits in livestock

Success ratea

Monthsb

Proceduresc

Cumulative benefitd

Dominant (%)

Recessive (%)

1.00

0.0

7072

96.1

92.4

0.80

+ 0.7

8184

95.5

91.0

0.60

− 2.4

9006

94.6

89.1

0.40

− 2.1

10,418

93.2

86.8

0.20

− 5.3

12,299

90.9

83.3

0.10

− 5.2

13,162

89.6

81.3

  1. Impact of editing success rate under moderate selection intensity for the desired allele combined with genome editing
  2. aSuccess rate of editing an undesired allele into the desired allele
  3. bLong-term loss (measured at generation 20) in months of selection response for the polygenic trait, compared to a success rate of 1.00
  4. cTotal number of editing procedures
  5. dPercentage of animals with the desired phenotype, cumulative over 20 generations, when the desired allele is either dominant or recessive