The impact of genome editing on the introduction of monogenic traits in livestock

Table 6 Long-term impact of survival rate of genome editing

Editing survival^a	Months^b	Procedures^c	Cumulative benefit^d
Editing survival^a	Months^b	Procedures^c	Dominant (%)	Recessive (%)
1.00	0.0	7072	96.1	92.4
0.80	− 1.5	7737	95.5	91.6
0.60	− 2.8	8109	95.1	90.8
0.40	− 5.1	8501	94.6	89.5
0.20	− 7.4	9514	93.2	87.5
0.05	− 12.8	11,071	90.5	83.6

Impact of editing survival rate under moderate selection intensity for the desired allele combined with genome editing
^aSurvival rate of zygotes subjected to editing
^bLong-term loss (measured at generation 20) in selection response for the polygenic trait, compared to complete survival
^cTotal number of editing procedures
^dPercentage of animals with the desired phenotype, cumulative over 20 generations, when the desired allele is either dominant or recessive

ISSN: 1297-9686