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Table 6 Long-term impact of survival rate of genome editing

From: The impact of genome editing on the introduction of monogenic traits in livestock

Editing survivala Monthsb Proceduresc Cumulative benefitd
Dominant (%) Recessive (%)
1.00 0.0 7072 96.1 92.4
0.80 − 1.5 7737 95.5 91.6
0.60 − 2.8 8109 95.1 90.8
0.40 − 5.1 8501 94.6 89.5
0.20 − 7.4 9514 93.2 87.5
0.05 − 12.8 11,071 90.5 83.6
  1. Impact of editing survival rate under moderate selection intensity for the desired allele combined with genome editing
  2. aSurvival rate of zygotes subjected to editing
  3. bLong-term loss (measured at generation 20) in selection response for the polygenic trait, compared to complete survival
  4. cTotal number of editing procedures
  5. dPercentage of animals with the desired phenotype, cumulative over 20 generations, when the desired allele is either dominant or recessive