The impact of genome editing on the introduction of monogenic traits in livestock

Table 8 Summary of results on the impact of genome editing and of reduced editing efficiency

Efficiency^a (%)	Measure	GS^b	GS + GE^c	Impact of GE^d (%)	Impact of efficiency^e (%)
100	Time to fixation (generations)	19	5	− 74
	Loss in polygenic trait response (months)	− 11.9	− 1.7	− 86
	inbreeding level in generation 20 (F)	0.06	0.06	0
	Undesired phenotypes (N)	58,800	15,600	− 73
	Editing procedures (N)		7072
4	Polygenic trait response (months)		− 15.3		+ 800
	Editing procedures (N)		12,144		+ 72

Values from scenarios with moderate selection emphasis on the desired allele (b₂ = 0.5)
^aPercentage of edited zygotes surviving to reproduction age, 100% from k = 1, s = 1, 4% from k = 0.2, s = 0.2 (Table 1)
^bValues from scenario with genomic selection only
^cValues from scenario combining genomic selection and genome editing
^dPercentage change between columns GS and GS + GE
^ePercentage change from GS + GE with 100% efficiency to GS + GE with 4% efficiency