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Table 8 Summary of results on the impact of genome editing and of reduced editing efficiency

From: The impact of genome editing on the introduction of monogenic traits in livestock

Efficiencya (%) Measure GSb GS + GEc Impact of GEd (%) Impact of efficiencye (%)
100 Time to fixation (generations) 19 5 − 74  
  Loss in polygenic trait response (months) − 11.9 − 1.7 − 86  
  inbreeding level in generation 20 (F) 0.06 0.06 0  
  Undesired phenotypes (N) 58,800 15,600 − 73  
  Editing procedures (N)   7072   
4 Polygenic trait response (months)   − 15.3   + 800
  Editing procedures (N)   12,144   + 72
  1. Values from scenarios with moderate selection emphasis on the desired allele (b2 = 0.5)
  2. aPercentage of edited zygotes surviving to reproduction age, 100% from k = 1, s = 1, 4% from k = 0.2, s = 0.2 (Table 1)
  3. bValues from scenario with genomic selection only
  4. cValues from scenario combining genomic selection and genome editing
  5. dPercentage change between columns GS and GS + GE
  6. ePercentage change from GS + GE with 100% efficiency to GS + GE with 4% efficiency