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Fig. 2 | Genetics Selection Evolution

Fig. 2

From: Remapping of the belted phenotype in cattle on BTA3 identifies a multiplication event as the candidate causal mutation

Fig. 2

cLDLA and NGS results. a Results of the cLDLA. The extended confidence interval (eCI) is shown in red; positions of the borders of the eCI and the genome-wide maximal LRT value are provided. b Ensembl genome browser result for the eCI. The grey bar above indicates the critical interval identified by Drögemüller et al. [5], the red bar indicates the candidate interval according to Drögemüller et al. [13], the blue bars indicate the inner candidate haplotypes (i.e. IC-Hap1 to 4 from left to right) identified by manual haplotype analysis of the eCI; the position of the 6-kb candidate segment (BeltMulti6kb) is marked with a yellow star; as shown, BeltMulti6kb is located next to the previously reported candidate haplotypes. c NGS results of BeltMulti6kb and surrounding regions. The first two lines show the coverage of homozygous belted animals (1. Dutch Belted = DBE, 2. Belted Galloway = BGA) and the third line shows a heterozygous belted crossbred, while the other lines show non-belted control animals (4. Jersey, 5. Simmental, 6. Holstein–Friesian, 7. Angus). SNPs are indicated by colored vertical lines within the coverage. The approximate extension of the multiplication event is provided. d Dotplot of the reference sequence of the 6-kb candidate segment against itself. Green circles highlight the obvious sequence similarity at the end and beginning of BeltMulti6kb

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