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Fig. 1 | Genetics Selection Evolution

Fig. 1

From: Misidentification of runs of homozygosity islands in cattle caused by interference with copy number variation or large intermarker distances

Fig. 1

BAF and LRR plots for scenarios with different copy numbers and homozygous alleles. The plots show how some regions that contain CNV can be erroneously determined as having ROH. The normal state is to carry two copies of an allele, and the BAF values are distributed between intermediate and extreme values, while the LRR ratio has intermediate values. As the number of copies increases, the LRR values move towards the higher extreme while the BAF values disperse into more intermediate values based on copy number. When the copy number is very large, this segment may also be mistyped as being homozygous and ROH algorithms may detect it as a ROH. A segment, which is truly homozygous has extreme BAF values and intermediate LRR values

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Genetics Selection Evolution

ISSN: 1297-9686