Fig. 1

Illustration of an individual viremia profile used to define stages of infection. Black dots represent log-transformed viremia measures, and the blue line represents the fitted Woods function over the time-course of infection (up to 42 dpi) for one individual. Early-stage of infection is defined from initial infection (0 dpi) to time when peak viremia (\({\text{V}}_{\rm{peak}}\)) is reached (\({\text{T}}_{\rm{peak}}\) in this example, approximately 6 dpi); mid-stage of infection is defined from \({\text{T}}_{\rm{peak}}\) to \({\text{T}}_{ \rm{max} }\) (\({\text{T}}_{ \rm{max} }\) in this example, approximately 19 dpi); and late-stage of infection, defined from \({\text{T}}_{ \rm{max} }\) to end of experiment (42 dpi, or 35 dpi for trials 7 and 8)