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Table 3 Number of significant SNPs influencing direct genetic effects and inflation factor for body weight recorded at different ages

From: Genome-wide associations and detection of potential candidate genes for direct genetic and maternal genetic effects influencing dairy cattle body weight at different ages

Trait

Dependent variable

Polygenic effect

FDRa

Bonferronib

λ

BW0

Phen

\({\mathbf{A}}\)

1213

64

1.92

\({\mathbf{G}}\)

7

3

0.96

LOCO

2268

125

2.22

LOCO_pruned

394

43

1.97

LOCO_SEG40

1811

103

2.06

LOCO_SEG441

80

17

1.29

LOCO_SEG864

41

12

1.18

LOCO + PC20

1132

73

1.90

LOCO + CHR_PC20

16

7

0.93

dDRP

\({\mathbf{A}}\)

1463

104

1.96

\({\mathbf{G}}\)

15

6

0.96

LOCO

2212

163

2.19

LOCO_pruned

414

54

1.91

LOCO_SEG40

1802

143

2.07

LOCO_SEG441

103

23

1.28

LOCO_SEG864

57

15

1.17

LOCO + PC20

1180

108

1.87

LOCO + CHR_PC20

13

8

0.90

BW23

Phen

\({\mathbf{A}}\)

11

0

1.17

\({\mathbf{G}}\)

0

0

0.99

LOCO + CHR_PC20

0

0

0.66

LOCO + CHR_PC10

0

0

0.93

dDRP

\({\mathbf{A}}\)

22

5

1.33

\({\mathbf{G}}\)

3

2

1.00

LOCO + CHR_PC20

0

0

0.70

LOCO + CHR_PC10

1

1

0.96

BW1314

Phen

\({\mathbf{A}}\)

47

14

1.46

\({\mathbf{G}}\)

5

3

0.97

LOCO + CHR_PC20

2

2

0.72

LOCO + CHR_PC10

7

4

0.98

dDRP

\({\mathbf{A}}\)

50

17

1.45

\({\mathbf{G}}\)

7

6

0.97

LOCO + CHR_PC20

3

3

0.72

LOCO + CHR_PC10

12

6

0.97

  1. FDR: false discovery rate; Bonferroni: Bonferroni correction; λ: inflation factor; BW0: body weight recorded at birth; BW23: body weight recorded at 2 to 3 month of age; BW1314: body weight recorded at 13 to 14 months of age; dDRP: de-regressed proofs for the direct genetic effect; mDRP: de-regressed proofs for the maternal genetic effect; LOCO_pruned: LOCO based on pruned SNPs
  2. aNumber of significant SNPs according to false discovery rate
  3. bNumber of significant SNPs according to Bonferroni-correction