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Table 5 Statistics for the AA14H3, CH19H2, and SI16H5 haplotypes

From: Analysis of a large dataset reveals haplotypes carrying putatively recessive lethal and semi-lethal alleles with pleiotropic effects on economically important traits in beef cattle

Haplotype

AA14H3

CH19H2

SI16H5

Genotyped animals

22,510

38,960

11,559

Frequency (%)

15.2

14.4

8.8

Recessive homozygotes

95

83

0

Expected recessive homozygotes

194.1

256

47.6

Sire-carrier × dam-carrier matings

220

256

17

Recessive homozygotes from sire-carrier × dam-carrier matings

2

6

0

Expected recessive homozygotes from sire-carrier × dam-carrier matings

55

64

4.3

Sire-carrier × maternal grand-sire-carrier matings

141

87

7

Recessive homozygotes from sire-carrier × maternal grand-sire-carrier matings

0

1

0

Expected recessive homozygotes from sire-carrier × maternal grand-sire-carrier matings

17.6

10.9

0.9

Probability of not observing recessive homozygotes with the T1 testa

2.3 × 10−85

2.5 × 10−112

2.0 × 10−21

Probability of not observing recessive homozygotes with the T2 testa

3.3 × 10−28

1.0 × 10−32

7.9 × 10−3

Probability of not observing recessive homozygotes with the T3 testa

6.7 × 10−9

9.0 × 10−9

3.9 × 10−1

Probability that the observed and expected number of recessive homozygotes are not different with the T4 testa

1.1 × 10−16

1.1 × 10−16

1.7 × 10−2

Probability that the observed and expected number of recessive homozygotes are not different with the T5 testa

7.2 × 10−6

1.4 × 10−3

3.2 × 10−1

  1. aT1: population test; T2: carrier mating test on sire × dam matings; T3: carrier mating test on sire × maternal grand-sire matings; T4: semi-lethality test on sire × dam matings; T5: semi-lethality test on sire × maternal grand-sire mating