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Table 1 Enrichment of four annotation categories and their category-based significance thresholds

From: Weighting sequence variants based on their annotation increases the power of genome-wide association studies in dairy cattle

Category

Number of possible causal variants

Enrichment

Confidence interval

Category-based significance threshold

High impact

19

0.017

− 0.00013 to 0.034

NA*

Moderate impact

391

4.40

3.84–4.96

6.88e−9

Low impact

799

245.45

236.44–254.45

3.84e−7

Other

102,214

0.89

0.88–0.89

NA*

  1. The confidence interval for each degree of enrichment is the 95% confidence interval obtained from bootstrapping resampled QTL 100 times
  2. *Indicates that the category-based significance was not calculated for this annotation class since there was no enrichment for this category