Table 5 Transcription factors (TFs) identified as key regulators of milk cheese-making and composition traits from both binding-site motifs and ChIP-Seq datasets, which presented significant normalized enrichment scores (NES)
TF | NES | Number of binding site motifs | Number of ChIP-Seq datasets | Number of target genes | Chromosome | Gene start (bp) | Gene end (bp) | Gene description |
|---|---|---|---|---|---|---|---|---|
HSPA1L | 4.90 | 5 | 1 | 261 | 23 | 27,334,344 | 27,338,328 | Heat shock 70 kDa protein 1-like |
SMAD5 | 4.63 | 4 | 2 | 253 | 7 | 49,155,483 | 49,217,780 | SMAD family member 5 |
HNF1B | 4.56 | 3 | 5 | 242 | 19 | 14,287,673 | 14,349,579 | HNF1 homeobox B |
SMAP2 | 4.30 | 7 | 1 | 236 | 3 | 106,311,859 | 106,358,978 | Small ArfGAP2 |
TFAP2A | 4.29 | 3 | 1 | 233 | 23 | 45,480,546 | 45,499,034 | Transcription factor AP-2 alpha |
BCL11A | 4.25 | 5 | 1 | 195 | 11 | 43,071,977 | 43,174,031 | B Cell CLL/Lymphoma 11A |
SMAD3 | 4.02 | 3 | 1 | 170 | 10 | 13,958,174 | 13,980,371 | SMAD family member 3 |
RXRA | 3.49 | 2 | 1 | 136 | 11 | 105,990,344 | 106,015,000 | Retinoid X receptor alpha |