Fig. 2

QTL analysis of chromosome 22 with variants color-coded according to predicted functional impact using SNPEff. a 1-Mb window of imputed whole-genome sequence association data centred around the top variant Chr22 g.31769747A>G (rs209784468) with the corresponding annotated gene track above. b 1-Mb window of imputed sequence association data with rs209784468 fitted as a fixed effect in the association model. The red line indicates the genome-wide significance threshold p = 5×10⁻⁸