An eQTL in the cystathionine beta synthase gene is linked to osteoporosis in laying hens

Table 2 Significance of association between SNPs on chromosome 1 and tibial breaking strength in hens at 70 weeks of age

Marker name	GalGal6 chr 1 position (bp)	F statistic	P value	Heterozygote effect (Newton)	Homozygote effect (Newton)
Ost92365348	90,332,842	0.22	0.802
Ost99883015	97,883,872	1.6	0.203
Ost101413556	99,395,470	2.04	0.131
Ost106225194	104,084,042	7.45	< 0.001	6.08	16.02
Ost106460620	104,314,846	2.88	0.057
Ost106823022	104,678,816	3.85	0.022	12.77	2.62
Ost106940170	104,834,987	4.9	0.008	6.336	17.15
Ost107389494	105,280,127	6.3	0.002	13.2	− 1.65
Ost107766125	105,655,660	5.58	0.004	12.61	4.83
Ost108015093	105,901,013	5.59	0.004	12.69	4.82
Ost109151638	107,036,767	3.17	0.042	− 7.75	− 16.75
Ost109151769	107,036,898	3.17	0.042	9.00	16.75
Ost110373245	108,261,209	3.18	0.042	− 0.58	− 8.29
Ost110455031	108,342,396	5.49	0.004	6.59	18.46
Ost112374543	110,246,492	3.51	0.03	− 2.98	− 12.63
Ost112522587	110,393,717	6.34	0.002	9.92	16.55
Ost113740421	111,546,531	1.59	0.205
Ost113743229	111,549,338	1.29	0.276
Ost114648871	112,392,632	0.99	0.372
Ost115611476	113,329,344	3.66	0.026	− 3.8	− 11.13
Ost115617544	113,335,412	0.44	0.647
Ost115655839	113,373,156	2.47	0.085
Ost115861595	113,578,876	1.97	0.14
Ost115862305	113,579,586	1.78	0.17
Ost115865281	113,582,562	1.4	0.248
Ost115866264	113,583,545	0.16	0.92
Ost121757410	119,732,454	0.2	0.821
Ost121237272	119,214,984	6.19	0.013	− 7.67
Ost126455926	124,863,293	0.27	0.601
Ost129219873	126,721,130	5.68	0.004	− 46.2	− 61.66
Ost134239048	131,424,865	0.14	0.872
Ost134239237	131,425,054	0.14	0.872

F values were obtained by REML analysis with body weight, hatch, total eggs and eggs in the 3 days before death as fixed effects, and sire and dam as random effects. Effect sizes are quoted relative to the reference homozygote only for the SNPs that had a nominal significance level lower than 0.05. If corrected for multiple testing and taking the identification of seven blocks containing 23 SNPs using Haploview [40] into account, then the significance after Bonferroni correction should be set at 0.003. The SNPs passing this threshold are in italic characters. The additive effect represents half that of the homozygote reference

ISSN: 1297-9686