From: Evaluation of sequencing strategies for whole-genome imputation with hybrid peeling
Pedigree | Variable coveragea | Uniform coverage at equal total coverageb | Uniform coverage at equal investmentc | Coverage of 2× at equal investmentd | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Number of individuals sequenced | Total coverage (x) | Investment (MUe) | Individual coverage (x) | Investment (MUe) | Individual coverage (x) | Number of individuals sequenced | |||||
Total | 1x | 2x | 5x | 15x | 30x | |||||||
2 × 2000 | 223 | 161 | 47 | 0 | 8 | 7 | 585 | 38,670 | 2.62 | 55,720 | 1.67 | 193 |
5 × 2000 | 561 | 403 | 119 | 1 | 27 | 11 | 1381 | 95,450 | 2.46 | 132,920 | 1.63 | 477 |
10 × 2000 | 1130 | 813 | 237 | 4 | 56 | 20 | 2747 | 191,720 | 2.43 | 264,960 | 1.62 | 958 |
15 × 2000 | 1703 | 1223 | 355 | 11 | 89 | 25 | 4073 | 288,350 | 2.39 | 393,960 | 1.62 | 1441 |
Real 15k | 877 | 632 | 182 | 3 | 50 | 10 | 2061 | 147,060 | 2.35 | 199,960 | 1.60 | 735 |
Real 30k | 1642 | 1245 | 281 | 9 | 76 | 31 | 3922 | 273,910 | 2.39 | 379,440 | 1.59 | 1369 |
Real 65k | 3742 | 2711 | 773 | 37 | 156 | 65 | 8732 | 629,450 | 2.33 | 848,240 | 1.60 | 3147 |