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Table 2 Number of sequenced individuals, distribution of sequencing coverages, total coverage, and total investment for the different populations with the Combined method with variable or uniform coverage

From: Evaluation of sequencing strategies for whole-genome imputation with hybrid peeling

Pedigree

Variable coveragea

Uniform coverage at equal total coverageb

Uniform coverage at equal investmentc

Coverage of 2× at equal investmentd

 

Number of individuals sequenced

Total coverage (x)

Investment (MUe)

Individual coverage (x)

Investment (MUe)

Individual coverage (x)

Number of individuals sequenced

Total

1x

2x

5x

15x

30x

2 × 2000

223

161

47

0

8

7

585

38,670

2.62

55,720

1.67

193

5 × 2000

561

403

119

1

27

11

1381

95,450

2.46

132,920

1.63

477

10 × 2000

1130

813

237

4

56

20

2747

191,720

2.43

264,960

1.62

958

15 × 2000

1703

1223

355

11

89

25

4073

288,350

2.39

393,960

1.62

1441

Real 15k

877

632

182

3

50

10

2061

147,060

2.35

199,960

1.60

735

Real 30k

1642

1245

281

9

76

31

3922

273,910

2.39

379,440

1.59

1369

Real 65k

3742

2711

773

37

156

65

8732

629,450

2.33

848,240

1.60

3147

  1. aResults obtained with the Combined method with an investment equivalent to 5% of the population sequenced at 2×
  2. bTotal coverage obtained with the Combined method distributed uniformly across the same individuals
  3. cInvestment allocated with the Combined method distributed uniformly across the same individuals
  4. dInvestment allocated with the Combined method distributed uniformly across as many individuals as can be sequenced at 2×
  5. eMonetary units
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Genetics Selection Evolution

ISSN: 1297-9686