Genetic control of temperament traits across species: association of autism spectrum disorder risk genes with cattle temperament

Table 2 Estimated lead variants within ± 100 kb of ASD genes associated with cattle flight time in the meta-analysis

Chr	Bp	A1/A2	Freq (A1)	b (A1)	P	%Vg^a	Dir^b	Variant type	Candidate genes^c
2	113,546,307	T/C	0.222	− 0.082	2.3 × 10⁻⁵	0.90	–	Intergenic	CUL3 (59 kb)
21	4,115,188	A/G	0.344	− 0.072	8.0 × 10⁻⁶	0.90	-+-	Intergenic	GABRB3 (28 kb)

Lead variants are obtained using clumping for all variants with P < 1 × 10⁻⁴, clumping windows of 5 Mb and r² = 0.1
^a%Vg = 2*Freq_A1*Freq_A2*b²/Vg*100, Vg = 0.259 (TropComp2)
^bDirection of SNP effect in each cohort of the meta-analysis (TropComp1, Brahman, TropComp2)
^cProtein-coding genes within 200 kb of the clumping window. Distance from top variant in parenthesis

ISSN: 1297-9686