Chr
|
Bp
|
A1/A2
|
Freq (A1)
|
b (A1)
|
P
|
%Vga
|
Dirb
|
Variant type
|
Candidate genesc
|
---|
2
|
113,546,307
|
T/C
|
0.222
|
− 0.082
|
2.3 × 10−5
|
0.90
|
–
|
Intergenic
|
CUL3 (59 kb)
|
21
|
4,115,188
|
A/G
|
0.344
|
− 0.072
|
8.0 × 10−6
|
0.90
|
-+-
|
Intergenic
|
GABRB3 (28 kb)
|
- Lead variants are obtained using clumping for all variants with P < 1 × 10−4, clumping windows of 5 Mb and r2 = 0.1
- a%Vg = 2*FreqA1*FreqA2*b2/Vg*100, Vg = 0.259 (TropComp2)
- bDirection of SNP effect in each cohort of the meta-analysis (TropComp1, Brahman, TropComp2)
- cProtein-coding genes within 200 kb of the clumping window. Distance from top variant in parenthesis