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Table 3 Terms significantly associated with genes within 50 kb of hair shedding GWAA variants with FDR < 0.05

From: Development of a genetic evaluation for hair shedding in American Angus cattle to improve thermotolerance

Term

Ontology source

p-value

Associated genes

Modulation by virus of host morphology or physiology

GO BP

< 0.001

ATG7, SMAD3, VAPB, ZC3H12A

Modification by symbiont of host morphology or physiology

GO BP

< 0.001

ATG7, SMAD3, VAPB, ZC3H12A

Modification of morphology or physiology of other organism involved in symbiotic interaction

GO BP

0.004

ATG7, SMAD3, VAPB, ZC3H12A, ZNF502

Modification of morphology or physiology of other organism

GO BP

0.008

ATG7, SMAD3, VAPB, ZC3H12A, ZNF502

Interaction with host

GO BP

0.010

ATG7, SMAD3, VAPB, ZC3H12A, ZNF502

dsRNA fragmentation

GO BP

0.014

SNIP1, TARBP2, ZC3H12A

Production of small RNA involved in gene silencing by RNA

GO BP

0.014

SNIP1, TARBP2, ZC3H12A

Production of miRNAs involved in gene silencing by miRNA

GO BP

0.015

SNIP1, TARBP2, ZC3H12A

Gene silencing by miRNA

GO BP

0.020

SNIP1, TARBP2, ZC3H12A

Positive regulation of fat cell differentiation

GO BP

0.020

PRDM16, SH3PXD2B, ZC3H12A

Cellular response to extracellular stimulus

GO BP

0.021

AQP3, ATF4, ATG7, KLF10, ZC3H12A

Cellular response to dsRNA

GO BP

0.021

SNIP1, TARBP2, ZC3H12A

Vasopressin-regulated water reabsorption

KEGG

0.021

AQP3, LOC784058, RAB11A

Posttranscriptional gene silencing

GO BP

0.022

SNIP1, TARBP2, ZC3H12A

Regulation of viral genome replication

GO BP

0.022

TARBP2, VAPB, ZC3H12A

Posttranscriptional gene silencing by RNA

GO BP

0.022

SNIP1, TARBP2, ZC3H12A

Positive regulation of viral life cycle

GO BP

0.022

TARBP2, VAPB, ZNF502

Prolactin signaling pathway

KEGG

0.022

LOC100336962, PRP-VII, PRP14, PRP9

Regulation of viral life cycle

GO BP

0.022

TARBP2, VAPB, ZC3H12A, ZNF502

Cellular response to starvation

GO BP

0.023

ATF4, ATG7, KLF10, ZC3H12A

Regulation of mitochondrion organization

GO BP

0.024

MIEF1, PEMT, SNIP1, TRIAP1, WDR75

Positive regulation of mitochondrion organization

GO BP

0.024

MIEF1, PEMT, SNIP1, WDR75

Cellular response to nutrient levels

GO BP

0.024

AQP3, ATF4, ATG7, KLF10, ZC3H12A

Regulation of fat cell differentiation

GO BP

0.024

PRDM16, SH3PXD2B, SMAD3, ZC3H12A

Response to dsRNA

GO BP

0.024

IFNE, SNIP1, TARBP2, ZC3H12A

Regulation of viral process

GO BP

0.025

TARBP2, VAPB, ZC3H12A, ZNF502

Viral genome replication

GO BP

0.025

TARBP2, VAPB, ZC3H12A

Regulation of protein targeting to mitochondrion

GO BP

0.025

PEMT, SNIP1, WDR75

Gene silencing by RNA

GO BP

0.025

SNIP1, TARBP2, ZC3H12A

Osteoclast differentiation

GO BP

0.025

EPHA2, KLF10, OSTM1

Regulation of establishment of protein localization to mitochondrion

GO BP

0.025

PEMT, SNIP1, WDR75

Oxidative phosphorylation

GO BP

0.025

COX6A1, NDUFA12, TEFM

Response to starvation

GO BP

0.025

ATF4, ATG7, KLF10, ZC3H12A

Negative regulation of defense response

GO BP

0.026

KRT1, SMAD3, TARBP2, ZC3H12A

Positive regulation of viral process

GO BP

0.026

TARBP2, VAPB, ZNF502

Positive regulation of establishment of protein localization to mitochondrion

GO BP

0.026

PEMT, SNIP1, WDR75

Positive regulation of protein targeting to mitochondrion

GO BP

0.026

PEMT, SNIP1, WDR75

Negative regulation of inflammatory response

GO BP

0.036

KRT1, SMAD3, ZC3H12A

Ribosome biogenesis in eukaryotes

KEGG

0.039

GNL2, NOL6, WDR75

Regulation of protein targeting

GO BP

0.041

PEMT, SNIP1, WDR75

  1. We find enrichment for pathways involved in virus-host interaction, response to starvation, prolactin signalling, and other biological processes. P-value are corrected for multiple testing using Benjamini–Hochberg methodology. Enrichments represent gene ontology biological process (GO BP) or Kyoto Encyclopedia of Genes and Genomes pathways (KEGG)