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Fig. 5 | Genetics Selection Evolution

Fig. 5

From: A 50-kb deletion disrupting the RSPO2 gene is associated with tetradysmelia in Holstein Friesian cattle

Fig. 5

Adapted from Szenker-Ravi et al. [22] b Multispecies alignment of the RSPO2 protein sequence. The amino acids affected by the deletion are indicated in light green; RSPO2 is highly conserved across investigated vertebrate species. The sequences for the alignment were taken from the following accessions: NP_001193021.1 (cattle), NP_848660.3 and XP_016868884.1 (human), XP_014953325.1 (sheep), XP_005689216.1 (goat), NP_001103151.1 (horse), NP_001280070.1 (pig), NP_001305953.1 (chicken), NP_001344885.1 (mouse), XP_008763677.1 (rat) and NP_001268919.1 (zebrafish)

Genomic and protein structure of bovine RSPO2. a RSPO2 genomic (top) and protein (bottom) structures with identified structural variant. Protein domains are indicated. Ex, exon. UTR, untranslated region.

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