Fig. 4

pCADD scores per intron compared to all other introns, for the first 20 introns. The blue bar indicates the number of introns tested against the intron of interest, the red bar shows how many of these tests resulted in an adjusted p-value < 0.05 (scale on the left axis). As the intron position increases, the number of tests that can be conducted decreases (with the number of transcripts that have at least that many introns). The black line represents the normalised number of significantly enriched introns, normalized by the number of conducted tests per intron position (scale on the right axis)