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Table 4 Test results between tissue-specific gene sets and housekeeping genes

From: pCADD: SNV prioritisation in Sus scrofa

Tissue

pCADD p-value (tissue < housekeeping)

pCADD ROC-AUC (housekeeping vs. tissue)

PhyloP p-value (tissue < housekeeping)

PhyloP ROC-AUC (housekeeping vs. tissue)

All tissues

2 × 10−1

0.500

1

0.467

Blood

3 × 10−122

0.512

1

0.481

Cartilage-Tendon

3 × 10−35

0.511

1

0.453

Cerebellum

1

0.480

1

0.487

Dermal

0

0.622

0

0.681

Epithelium

0

0.538

1 × 10−29

0.515

Eye

1

0.475

1

0.456

Kidney

2 × 10−100

0.515

1

0.468

Liver

1 × 10−54

0.510

9 × 10−1

0.490

Lung

6 × 10−8

0.506

1 × 10−2

0.503

Muscle

1

0.491

1

0.468

Neuronal

1

0.443

1

0.400

Pancreas

1 × 10−310

0.558

3 × 10−81

0.559

Placenta

1 × 10−145

0.529

1

0.469

Salivary-gland

7 × 10−48

0.519

1

0.478

Testis

0

0.558

1

0.478

Vasculature

0

0.558

1

0.454

  1. We tested if tissue-specific genes have significantly lower pCADD scores than housekeeping genes, using pCADD and PhyloP scores (25-taxa mammalian alignment). The ROC-AUC scores display the likelihood that a random sample from the scores of the housekeeping genes is greater than that from the scores of tissue-specific genes