Fig. 5

Feature set enrichment analyses (FSEA) of differentially expressed (DE) genes between animals with divergent Ab responses to M. hyo vaccination. The CERNO test was operated on lists of genes that were ranked by their absolute log FC of the DE analyses that compare groups of contrasted responders to vaccination at 21, 28, 35, and 118 dpv (high vs low or positive vs negative). BTM significantly enriched in each list (p < 0.01 and AUC > 0.75) are represented in rows. BTM are named by their title and ID in parenthesis. The strength of the p-value is illustrated by the transparency of color; the effect size (AUC) is illustrated with the plot size. Significantly (p < 0.05) up-regulated genes in high or positive responders are colored in blue and downregulated genes are colored in orange; the others are in grey. (TBA = to be annotated)