TY - JOUR AU - Fernandes Júnior, Gerardo A. AU - Carvalheiro, Roberto AU - de Oliveira, Henrique N. AU - Sargolzaei, Mehdi AU - Costilla, Roy AU - Ventura, Ricardo V. AU - Fonseca, Larissa F. S. AU - Neves, Haroldo H. R. AU - Hayes, Ben J. AU - de Albuquerque, Lucia G. PY - 2021 DA - 2021/03/12 TI - Imputation accuracy to whole-genome sequence in Nellore cattle JO - Genetics Selection Evolution SP - 27 VL - 53 IS - 1 AB - A cost-effective strategy to explore the complete DNA sequence in animals for genetic evaluation purposes is to sequence key ancestors of a population, followed by imputation mechanisms to infer marker genotypes that were not originally reported in a target population of animals genotyped with single nucleotide polymorphism (SNP) panels. The feasibility of this process relies on the accuracy of the genotype imputation in that population, particularly for potential causal mutations which may be at low frequency and either within genes or regulatory regions. The objective of the present study was to investigate the imputation accuracy to the sequence level in a Nellore beef cattle population, including that for variants in annotation classes which are more likely to be functional. SN - 1297-9686 UR - https://doi.org/10.1186/s12711-021-00622-5 DO - 10.1186/s12711-021-00622-5 ID - Fernandes Júnior2021 ER -