Skip to main content

Table 3 Top significant associations after correction for multiple testing (q-value < 0.1) between miRNA SNPs and the mRNA expression of their potential targets in the gluteus medius (GM) skeletal muscle (N = 89) and liver (N = 87) tissue samples from Duroc pigs

From: Variability in porcine microRNA genes and its association with mRNA expression and lipid phenotypes

SNP (chromosome position)

Type

Tissue

Probe

ID

Gene

δa

seb

P-value

q-valuec

rs333787816 (2:65,308,181 bp)

ssc-miR-23a precursor stem (T/C)

GM

Ssc.1790.1.S1_at

ENSSSCG00000000019

NUP50

− 0.1052

0.0288

3.849E−04

6.157E−02

Ssc.12493.1.A1_at

ENSSSCG00000024027

PAFAH1B2

− 0.2021

0.0565

3.921E−04

6.157E−02

Ssc.13786.1.A1_at

ENSSSCG00000003857

ZYG11B

0.2614

0.0730

4.341E−04

6.157E−02

Ssc.8682.2.A1_at

ENSSSCG00000014240

CSNK1G3

− 0.1532

0.0434

4.515E−04

6.157E−02

Ssc.23976.1.S1_at

ENSSSCG00000012252

DDX3X

− 0.4318

0.1217

5.095E−04

6.157E−02

Ssc.4948.1.S1_at

ENSSSCG00000034725

UBE2R2

0.1726

0.0493

5.906E−04

6.157E−02

Ssc.21303.1.S1_at

ENSSSCG00000003630

AGO1

0.1016

0.0275

6.775E−04

6.157E−02

Ssc.24035.2.A1_at

ENSSSCG00000005935

AGO2

0.2896

0.0864

8.339E−04

6.157E−02

Ssc.3706.1.S2_at

ENSSSCG00000040317

SOD2

− 0.2987

0.0896

8.880E−04

6.157E−02

Ssc.3706.1.S1_at

ENSSSCG00000040317

SOD2

− 0.4224

0.1261

8.884E−04

6.157E−02

rs319154814 (9:9,581,989 bp)

ssc-miR-326 apical loop (G/A)

LIVER

Ssc.9544.2.S1_a_at

ENSSSCG00000016101

CFLAR

0.3246

0.0997

1.264E−03

5.785E−02

Ssc.11661.2.S1_at

ENSSSCG00000009828

PPP1CC

0.4508

0.1436

1.784E−03

5.785E−02

Ssc.31172.3.S1_at

ENSSSCG00000008601

SDC1

0.2507

0.0808

2.486E−03

5.785E−02

Ssc.11044.1.A1_at

ENSSSCG00000003643

SF3A3

0.1808

0.0561

2.598E−03

5.785E−02

Ssc.23242.1.A1_at

ENSSSCG00000039426

FSTL1

0.2407

0.078

2.606E−03

5.785E−02

Ssc.12222.1.S1_at

ENSSSCG00000013233

CELF1

− 0.1714

0.0574

3.210E−03

5.939E−02

Ssc.10946.2.A1_at

ENSSSCG00000011917

NAA50

0.2853

0.0993

4.070E−03

6.454E−02

Ssc.4516.2.S1_at

ENSSSCG00000013592

ELAVL1

0.1666

0.0598

6.226E−03

8.639E−02

  1. In this analysis, we consider only the expression of mRNAs with 3′UTR sites complementary to the seeds of the investigated miRNAs and with such interactions having been functionally validated in humans (see “Methods” for more information)
  2. aδ: estimated allele substitution effect
  3. bse: standard error of the substitution effect
  4. cq-value: q-value calculated with the false discovery rate (FDR) approach [65]
Back to article page

Genetics Selection Evolution

ISSN: 1297-9686