Table 4 Significant associations at the nominal level (P-value < 0.01) and after multiple testing correction (q-value < 0.1; in italics) between 12 genotyped miRNA SNPs and lipid phenotypes recorded in a population of Duroc pigs (N = 345)
From: Variability in porcine microRNA genes and its association with mRNA expression and lipid phenotypes
SNP (chromosome position) | Type | Trait | δ | se | P-value | q-value |
|---|---|---|---|---|---|---|
rs81349391 (1:164,026,014 bp) | ssc-miR-339 apical loop (A/G) | GM (C16:0) | − 0.3234 | 0.1396 | 2.005E−02 | 3.772E−01 |
GM SFA | − 0.4394 | 0.2030 | 2.969E−02 | 3.772E−01 | ||
GM UFA | 0.4392 | 0.2030 | 2.978E−02 | 3.772E−01 | ||
rs344472188 (2:13,296,736 bp) | ssc-miR-130a apical loop (T/C) | BFTLR | − 1.2084 | 0.5914 | 4.087E−02 | 9.683E−01 |
rs340704946 (4:6,948,743 bp) | ssc-miR-30d precursor stem (A/G) | GM (C20:0) | − 0.0219 | 0.0098 | 2.541E−02 | 5.779E−01 |
rs320008166 (6:56,427,227 bp) | ssc-miR-371 precursor stem (T/C) | GM IMF | 0.5368 | 0.2461 | 3.104E−02 | 9.060E−01 |
rs323906663 (6:63,491,948 bp) | ssc-miR-429 precursor stem (G/A) | GM IMF | 0.5682 | 0.2482 | 2.348E−02 | 8.923E−01 |
rs319154814 (9:9,581,989 bp) | ssc-miR-326 apical loop (G/A) | LD (C14:0) | 0.0885 | 0.0213 | 8.722E−05 | 3.314E−03 |
GM (C14:0) | 0.0700 | 0.0184 | 3.942E−04 | 7.489E−03 | ||
LD PUFA/MUFA | − 0.0506 | 0.0188 | 7.109E−03 | 7.653E−02 | ||
LD (C20:1) | 0.0349 | 0.0125 | 8.055E−03 | 7.653E−02 | ||
LD (C20:4) | − 0.2918 | 0.1268 | 2.092E−02 | 1.438E−01 | ||
LD MUFA | 0.9512 | 0.3971 | 2.485E−02 | 1.438E−01 | ||
LD (C18:1) | 0.8349 | 0.3624 | 2.814E−02 | 1.438E−01 | ||
LD PUFA | − 1.0670 | 0.5004 | 3.222E−02 | 1.438E−01 | ||
LD (C18:2) | − 0.7266 | 0.3443 | 3.405E−02 | 1.438E−01 | ||
GM (C18:0) | − 0.2245 | 0.1115 | 4.423E−02 | 1.681E−01 | ||
rs321151601 (9:39,280,312 bp) | ssc-miR-34c mature region (C/A) | LD (C20:0) | − 0.0262 | 0.0119 | 2.655E−02 | 8.171E−01 |
rs335924546 (17:10,758,828Â bp) | ssc-miR-486 precursor stem (C/T) | GM (C20:4) | 0.3396 | 0.1465 | 2.100E-02 | 4.555E-01 |
LD (C14:0) | − 0.0586 | 0.0256 | 2.937E−02 | 4.555E−01 | ||
LD IMF | 0.3300 | 0.1553 | 4.748E−02 | 4.555E−01 | ||
rs334590580 (18:18,341,582 bp) | ssc-miR-335 precursor stem (T/C) | GM (C16:0) | − 0.4305 | 0.1558 | 5.862E−03 | 1.201E−01 |
GM (C20:0) | 0.0331 | 0.0121 | 6.321E−03 | 1.201E−01 | ||
GM UFA | 0.5231 | 0.2278 | 2.147E−02 | 2.045E−01 | ||
GM SFA | − 0.5229 | 0.2278 | 2.153E−02 | 2.045E−01 |