Caprine PRNP polymorphisms N146S and Q222K are associated with proteolytic cleavage of PrPC

Table 2 C1 percentage of total PrP^C by PRNP genotype in goats

PRNP Genotype 142–143–146–222	Number of goats	Mean C1% of total PrP^C (± standard deviation)
All goats	50	49.7 ± 13.5
Genotype
II–HH–NN–QQ^a	22	46.9 ± 9.3
IM–HH–NN–QQ	3	41.9 ± 10.4
II–HR–NN–QQ	5	53.8 ± 6.7
II–RR–NN–QQ	5	47.2 ± 9.2
II–HH–NS–QQ	5	33.7 ± 3.2*
II–HH–NS–QK	2	62.5 ± 32.3
II–HH–NN–QK	6	67.8 ± 11.8*
II–HH–NN–KK	2	60.9 ± 16.1

^aII₁₄₂–HH₁₄₃–NN₁₄₆–QQ₂₂₂ is wild type caprine PRNP
^*Mean percent C1 of total PrP^C that is significantly different from wild type (n = 22) at p < 0.05

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