Table 1 Proposed causative variants in cattle

ABCG2 (p.Tyr581Ser)

Milk yield and composition

Missense SNV

NC_037333.1:g.36599640A > C

ENSBTAP00000051068:p.Tyr581Ser

A has higher milk yield and lower fat and protein concentration

6:36,599,640

[24]

DGAT1 (p.Ala323Lys)

Milk yield and composition

Non-synonymous multinucleotide variant

NC_037341.1:g.611019_611020delinsAA

ENSBTAP00000037256:p.Ala323Lys

AA has higher milk yield and lower fat and protein concentration

14:611,019–611,020

[37]

GHR (p.Phe279Tyr)

Milk yield and composition

Missense SNV

NC_037347.1:g.31870098 T > A

ENSBTAP00000001758:p.Phe279Tyr

T has higher milk yield and lower fat and protein concentration

20:31,870,098

rs385640152

[45]

MSTN (p.Asp273fs)

Muscle growth (cattle)

Frameshift deletion

NC_037329.1:g.6283674_6283684del

ENSBTAP00000015674:p.Asp273fs

Deletion has more muscle

2:6,283,674–6,283,684

rs382669990

OMIA 000,683–9913

[48,49,50]

(p.Gln204*)

Stop gain SNV

NC_037329.1:g.6281434C > T

ENSBTAP00000015674:p.Gln204*

T has more muscle

2:6,281,434

rs110344317

(p.Glu226*)

Stop gain SNV

NC_037329.1:g.6281500G > T

ENSBTAP00000015674:p.Glu226*

T has more muscle

2:6,281,500

(p.Cys313Tyr)

Missense SNV

NC_037329.1:g.6283794G > A

ENSBTAP00000015674:p.Cys313Tyr

A has more muscle

2:6,283,794

(p.Phe140*)

Stop gain indel

NC_037329.1:g.6281243_6281249delinsAAGCATACAA

ENSBTAP00000015674:p.Phe140*

The long allele has more muscle

2:6,281,243–6,281,249

PRLR (p.Ala461fs)

Slick coat type

Frameshift deletion

NC_037347.1:g.39099214_delC

ENSBTAP00000069979:p.Ala461fs

Deletion has slick coat

20:39,099,214

rs517047387

OMIA 001,372–9913

[64, 65]

(p.Ser465*)

Stop gain SNV

NC_037347.1:g.39099226C > A

ENSBTAP00000069979:p.Ser465*

A has slick coat

20:39,099,226

(p.Arg497*)

Stop gain SNV

NC_037347.1:g.39099321C > T

ENSBTAP00000069979:p.Arg497*

T has slick coat

20:39,099,321