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Table 4 Functional candidate genes and previously reported QTL for backfat-related traits in the significant genomic regions

From: Genetic architecture and major genes for backfat thickness in pig lines of diverse genetic backgrounds

SSC

Position, Mb

Lines

Number of QTL

QTL traits

Number of positional candidate genes

Genes with related annotated functionsb

1

50.67–54.63

C, E, H

11

BFT*, DFI* (7), IMF, OI, RFI

43

CYB5R44,5

1

151.60–152.70

H

2

BFT*, DFI*

5

1

157.81–162.85

A, B, C, D, H

45

BFT* (3), BF10R (4), BFLR* (5), BFR, DFI* (13), FCR (2), IMF, LMP* (10), OI (6)

53

KDSR2, MC4R4

1

162.86–165.33

C

1

LMP*

45

ATP8B12,8, SLC51B2,8, CILP5, HACD32,3

1

268.68–271.74

A

6

AFW, BF10R (2), BFMB, BFW, FCR

83

SLC27A42,3,5, DOLK2, DOLPP12, CRAT3

2

0.00–4.82

C

64

BFT* (19), AFW, BF10R (3), BF34R (3), BFFR, BFLL (4), BFLR* (7), BFR (7), BFW, FCR (6), LMP* (12)

138

PTDSS22, HRAS5,6, PNPLA22,3, BRSK25, IGF24, INS1,2,4,5, DHCR77, FGF194, CPT1A2,3,5,6, GAL5, LRP51,5, CHKA2

2

60.14–62.75

E

87

SLC27A13,5, SIN3B2

2

65.51–66.51

E

42

GCDH3

2

68.62–69.76

A

53

RDH87, CARM11,2

2

70.83–72.11

A

1

IMF

52

ANGPTL42,3, CERS42, INSR2,4,5

2

73.34–74.42

A

25

PLIN51,2,3

2

75.25–76.34

A

3

BFT* (2), LMP*

35

S1PR42, GNA152, GNA115

2

76.41–77.41

A

47

MKNK25, ATP8B32, STK114,6, ABCA72

5

18.18–20.32

E

83

SOAT22,7, CALCOCO17

5

64.80–67.66

A, B, D, H

6

BFT*, BF34R (2), IMF(2), TGL

49

FGF237

5

68.90–69.90

D

2

BFT*, BFLR*

16

HDHD52

6

47.11–48.11

B

2

BFMD, IMF

59

SIRT21, ZFP361

6

146.99–147.99

C

14

BFT* (2), BF10R (5), BF34R, BFLL, BFLR* (3), IMF(2)

11

JAK16, LEPR4,6 (at 146.80–146.90 Mb)

7

29.60–31.39

B, C, F

23

BFT* (7), ADAR, AFW, BF34R, BF67R, BFFR, BFLR* (3), BFMB, BFR (2), FCR, LMP*, SSFT (3)

46

DAXX7, ITPR35, PPARD1,2,3

7

31.49–32.39

D

1

FCR

23

PNPLA12, CDKN1A6

11

6.53–10.07

A, C, E, H

2

BFT*, RFI

62

ALOX5AP3, MEDAG1

12

24.85–25.87

F

2

IMF (2)

35

GIP5, PHB7, NGFR4

15

103.57–105.40

G

32

15

118.63–119.63

F

3

BFT*, DFI*, LMP*

9

IGFBP25, IGFBP55

16

32.99–33.99

C

10

FCR (10)

6

18

7.82–12.28

A, B, D, H

8

BFT* (2), BFLR*, IMF (5)

71

AGK2, ATP6V0A45, AKR1D17,8, DGKI2, PTN1,7

18

12.60–13.60

D

1

BFR

9

  1. BFT average backfat thickness, ADAR adipocyte area, AFW abdominal fat weight, BF10R backfat thickness at tenth rib, BF34R backfat thickness between the third and fourth rib, BF67R backfat thickness between the sixth and seventh rib, BFFR backfat thickness at first rib, BFLL backfat thickness at last lumbar, BFLR backfat thickness at last rib, BFMB backfat thickness at mid-back, BFMD backfat thickness above muscle dorsi, BFR backfat thickness at rump, BFW backfat weight, DFI daily feed intake, FCR feed conversion ratio; IMF intramuscular fat content, LMP lean meat percentage, OI obesity index, RFI residual feed intake, SSFT shoulder subcutaneous fat thickness, TGL triglyceride level. Within parentheses: number of entries if there were more than one. *Enriched QTL traits (p < 10–4)
  2. Superscript numbers: 1Adipogenesis pathways; 2Lipid metabolism pathways; 3Fatty acid metabolism pathways; 4Energy homeostasis pathways; 5Insulin signalling pathways; 6Adipocytokines signalling pathways; 7Steroid hormone and vitamin D metabolism pathways; 8Bile acid metabolism