Association analysis and functional annotation of imputed sequence data within genomic regions influencing resistance to gastro-intestinal parasites detected by an LDLA approach in a nucleus flock of Sarda dairy sheep

Table 3 QTL regions from the LDLA analysis

QTLR	OAR	Range (bp)	nSNP	Pos (bp)	$- \log_{10} \left( {{Pvalue}} \right)$	${\raise0.7ex\hbox{${\widehat{{{\boldsymbol{\sigma}}_{{{\varvec{qtlS}}}}^{2} }}}$} \!\mathord{\left/ {\vphantom {{\widehat{{{\boldsymbol{\sigma}}_{{{\varvec{qtlS}}}}^{2} }}} {{\boldsymbol{\sigma}}_{{{\varvec{APD}}}}^{2} }}}\right.\kern-\nulldelimiterspace} \!\lower0.7ex\hbox{${{\boldsymbol{\sigma}}_{{{\varvec{APD}}}}^{2} }$}}$
Q_01_1	1	99,988,914–99,988,914	1	99,988,914	6.256	0.0087
Q_02_1	2	135,598,790–135,598,790	1	135,598,790	6.078	0.0093
Q_02_2	2	213,089,849–213,166,468	3	213,135,270	6.554	0.0093
Q_04_1	4	5,252,005–9,837,812	6	5,386,849	7.404	0.0111
Q_06_1	6	12,638,149–12,695,314	3	12,695,314	6.864	0.0099
Q_07_1	7	88,040,710–88,085,726	2	88,040,710	6.762	0.0098
Q_12_1	12	35,973,543–41,153,795	19	39,430,517	9.191	0.0125
Q_15_1	15	34,024,406–34,081,200	2	34024406	7.362	0.0110
Q_19_1	19	18,933,658–31,429,916	11	18,983,777	7.302	0.0104
Q_20_1	20	16,796,770–36,098,292	154	21,170,858	12.861	0.0176

QTLR: QTL region identifier; OAR Ovis aries autosome; Range: position, in bp from the ovine genome assembly v4.0, of the first and last significant SNP of the QTL region; nSNP number of SNPs from the OvineSNP50 Beadchip exceeding the 0.05 genome-wide significance threshold $- {\text{log}}_{10} \left( {Pvalue} \right) > 6$; Pos: position of the most significant SNP in bp; $- {\text{log}}_{10} \left( {Pvalue} \right)$: negative logarithm of the p-value of the most significant SNP; ${\raise0.7ex\hbox{${\widehat{{\sigma_{qtlS}^{2} }}}$} \!\mathord{\left/ {\vphantom {{\widehat{{\sigma_{qtlS}^{2} }}} {\widehat{{\sigma_{APD}^{2} }}}}}\right.\kern-\nulldelimiterspace} \!\lower0.7ex\hbox{${\widehat{{\sigma_{APD}^{2} }}}$}}$: ratio between the ANOVA estimator of the QTL variance at peak position ($\widehat{{\sigma_{qtlS}^{2} }}$) and the total phenotypic variance of the pseudo-phenotypes ($\widehat{{\sigma_{APD}^{2} }}$)

ISSN: 1297-9686