Using mid-infrared spectroscopy to increase GWAS power to detect QTL associated with blood urea nitrogen

Table 2 Positions of potential QTL detected for BUN and MBUN

Chr	Pos (bp)	Trait	p_BUN	p_MBUN	Annotation	Genes	Start (bp)	End (bp)	N
2	47,485,307	MBUN	6.5 × 10^–1	9.4 × 10^–7	Intron	EPC2	47,485,307	47,485,307	1
3	18,190,277	MBUN	3.1 × 10^–2	6.3 × 10^–7	Upstream	CRCT1	18,190,277	18,190,277	1
3	55,238,179	MBUN	1.2 × 10^–3	3.5 × 10^–7	Intergenic	PKN2-ENSBTAG00000051499	55,238,179	55,257,795	33
9	97,711,991	MBUN	3.0 × 10^–2	8.4 × 10^–7	Intron	PRKN	97,711,991	97,711,991	1
11	99,897,676	MBUN	4.1 × 10^–1	2.7 × 10^–7	Intron	ENSBTAG00000054738	99,897,676	99,916,846	6
11	103,271,858	MBUN	7.7 × 10^–1	7.7 × 10^–11	Synonymous	GLT6D1	101,401,373	103,606,366	382
11	105,110,370	MBUN	8.0 × 10^–1	6.8 × 10^–7	Intron	RXRA	105,110,370	105,110,370	1
12	84,682,464	MBUN	2.8 × 10^–1	6.0 × 10^–7	Intergenic	IRS2-RF00001	84,682,431	84,699,022	3
13	15,837,206	BUN	4.8 × 10^–7	6.6 × 10^–2	Intergenic	ENSBTAG00000048047-GATA3	15,835,519	15,839,775	5
14	631,698	MBUN	1.5 × 10^–1	8.6 × 10^–14	Upstream	BOP1	512,818	1,278,273	209
X	31,752,695	MBUN	2.7 × 10^–2	9.0 × 10^–7	Intergenic	ENSBTAG00000018311-IDS	31,752,695	31,752,695	1
X	100,768,475	MBUN	4.2 × 10^–1	2.7 × 10^–7	Intergenic	MAOA-PPP1R2C	100,768,475	100,768,475	1
X	107,587,617	MBUN	3.1 × 10^–1	8.7 × 10^–7	Intergenic	MAGEB16-ENSBTAG00000040406	107,587,617	107,587,617	1

BUN, blood urea nitrogen; MBUN, BUN predicted using mid-infrared spectroscopy; chr, chromosome; pos, position of the most significant variant associated with the QTL; trait, trait for which the QTL is significant; bp, base pair according to the ARS-UCD1.2 annotation; p_BUN, p-value in the GWAS for BUN; p_MBUN, p-value in the GWAS for MBUN; annotation, annotation of the most significant variant; gene, gene in which the most significant region was located or, if the most significant variant was intergenic, the genes between which the most significant variant was located, start, start of the QTL interval; end, end of the QTL interval; N, number of variants with p ≤ 10^–6 in the QTL interval

ISSN: 1297-9686