Table 6 Genomic windowsa that explain the highest proportion of genetic variance (Var%) for sole haemorrhage (SH), sole ulcer (SU), and white line disease (WL), including chromosome (BTA), positions of the window (Pos_start, Pos_end), and Bos taurus RefSeq gene(s) within the window
Lesion | Trait | BTA | Pos_start | Pos_end | Var% | RefSeq gene(s) within the window |
|---|---|---|---|---|---|---|
SH | Lesion susceptibility | 18 | 21,574,466 | 22,223,573 | 0.66 | RBL2, CHD9, AKTIP, FTO |
20 | 58,161,594 | 58,795,440 | 0.47 | ANKH, OTULIN, OTULINL, TRIO | ||
3 | 90,725,628 | 91,356,392 | 0.41 | BSND, TMEM61 | ||
Lesion severity | 20 | 58,161,594 | 58,795,440 | 0.77 | ANKH, OTULIN, OTULINL, TRIO | |
22 | 21,284,764 | 21,911,533 | 0.61 | ITPR1, BHLHE40, SUMF1 | ||
3 | 88,750,416 | 89,386,272 | 0.50 | C8B, C8A | ||
21 | 14,912,081 | 15,547,515 | 0.44 | SLCO3A1 | ||
24 | 6,860,561 | 7,499,698 | 0.38 | RTTN | ||
16 | 53,817,301 | 54,451,982 | 0.34 | PDPN | ||
1 | 137,657,855 | 138,268,870 | 0.33 | MIR2288 | ||
SU | Lesion susceptibility | 6 | 86,762,457 | 87,405,290 | 0.56 | GC, SLC4A4 |
18 | 21,422,708 | 22,070,855 | 0.41 | RBL2, CHD9, AKTIP, FTO | ||
Lesion severity | 14 | 8,954,477 | 9,597,429 | 0.86 | KCNQ3, EFR3A | |
18 | 21,454,669 | 22,081,129 | 0.70 | RBL2, CHD9, AKTIP, FTO | ||
14 | 5,922,777 | 6,526,644 | 0.52 | KHDRBS3 | ||
WL | Lesion susceptibility | 14 | 64,061,208 | 64,708,627 | 0.60 | POLR2K, RNF19A |
3 | 88,750,416 | 89,386,272 | 0.38 | C8B, C8A | ||
10 | 97,152,695 | 97,799,000 | 0.37 | – | ||
6 | 37,796,921 | 38,426,291 | 0.36 | – | ||
25 | 4,353,128 | 4,984,105 | 0.30 | – | ||
Lesion severity | 25 | 4,231,415 | 4,872,654 | 0.75 | – | |
6 | 37,412,062 | 38,055,681 | 0.72 | LCORL | ||
19 | 59,814,966 | 60,461,025 | 0.61 | – | ||
1 | 153,405,778 | 154,054,353 | 0.61 | PLCL2, DAZL | ||
1 | 155,049,738 | 155,696,507 | 0.49 | SATB1 | ||
3 | 89,466,489 | 90,090,412 | 0.49 | PLPP3, PRKAA2 | ||
17 | 5,843,870 | 6,493,219 | 0.48 | GATB |