Open Access

Detection of quantitative trait loci for growth and fatness in pigs

  • Jean-Pierre Bidanel1Email author,
  • Denis Milan2,
  • Nathalie Iannuccelli2,
  • Yves Amigues3,
  • Marie-Yvonne Boscher3,
  • Florence Bourgeois3,
  • Jean-Claude Caritez4,
  • Joseph Gruand5,
  • Pascale Le Roy1,
  • Hervé Lagant1,
  • Raquel Quintanilla1, 7,
  • Christine Renard6,
  • Joël Gellin2,
  • Louis Ollivier1 and
  • Claude Chevalet2
Genetics Selection Evolution200133:289

DOI: 10.1186/1297-9686-33-3-289

Received: 27 October 2000

Accepted: 11 January 2001

Published: 15 May 2001

Abstract

A quantitative trait locus (QTL) analysis of growth and fatness data from a three-generation experimental cross between Meishan (MS) and Large White (LW) pig breeds is presented. Six boars and 23 F1 sows, the progeny of six LW boars and six MS sows, produced 530 F2 males and 573 F2 females. Nine growth traits, i.e. body weight at birth and at 3, 10, 13, 17 and 22 weeks of age, average daily gain from birth to 3 weeks, from 3 to 10 weeks and from 10 to 22 weeks of age, as well as backfat thickness at 13, 17 and 22 weeks of age and at 40 and 60 kg live weight were analysed. Animals were typed for a total of 137 markers covering the entire porcine genome. Analyses were performed using two interval mapping methods: a line-cross (LC) regression method where founder lines were assumed to be fixed for different QTL alleles and a half-/full-sib (HFS) maximum likelihood method where allele substitution effects were estimated within each half-/full-sib family. Both methods revealed highly significant gene effects for growth on chromosomes 1, 4 and 7 and for backfat thickness on chromosomes 1, 4, 5, 7 and X, and significant gene effects on chromosome 6 for growth and backfat thickness. Suggestive QTLs were also revealed by both methods on chromosomes 2 and 3 for growth and 2 for backfat thickness. Significant gene effects were detected for growth on chromosomes 11, 13, 14, 16 and 18 and for backfat thickness on chromosome 8, 10, 13 and 14. LW alleles were associated with high growth rate and low backfat thickness, except for those of chromosome 7 and to a lesser extent early-growth alleles on chromosomes 1 and 2 and backfat thickness alleles on chromosome 6.

Keywords

pig gene mapping quantitative trait locus growth fatness

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Authors’ Affiliations

(1)
Institut national de la recherche agronomique, Station de génétique quantitative et appliquée
(2)
Institut national de la recherche agronomique, Laboratoire de génétique cellulaire
(3)
Institut national de la recherche agronomique, Labogéna
(4)
Institut national de la recherche agronomique, Domaine expérimental du Magneraud
(5)
Institut national de la recherche agronomique, Station expérimentale de sélection porcine
(6)
Institut national de la recherche agronomique, Laboratoire de radiobiologie et d'étude du génome
(7)
Departamento de Producción Agraria, Universidad Pública de Navarra

Copyright

© INRA, EDP Sciences 2001

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