A review on SNP and other types of molecular markers and their use in animal genetics

  • Alain Vignal1Email author,

    Affiliated with

    • Denis Milan1,

      Affiliated with

      • Magali SanCristobal1 and

        Affiliated with

        • André Eggen2

          Affiliated with

          Genetics Selection Evolution200234:275

          DOI: 10.1186/1297-9686-34-3-275

          Received: 11 February 2002

          Accepted: 8 March 2002

          Published: 15 May 2002


          During the last ten years, the use of molecular markers, revealing polymorphism at the DNA level, has been playing an increasing part in animal genetics studies. Amongst others, the microsatellite DNA marker has been the most widely used, due to its easy use by simple PCR, followed by a denaturing gel electrophoresis for allele size determination, and to the high degree of information provided by its large number of alleles per locus. Despite this, a new marker type, named SNP, for Single Nucleotide Polymorphism, is now on the scene and has gained high popularity, even though it is only a bi-allelic type of marker. In this review, we will discuss the reasons for this apparent step backwards, and the pertinence of the use of SNPs in animal genetics, in comparison with other marker types.

          SNP microsatellite molecular marker genome polymorphism

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          Authors’ Affiliations

          Laboratoire de génétique cellulaire, Inra, chemin de Borde-Rouge, Auzeville
          Laboratoire de génétique biochimique et de cytogénétique, Inra, domaine de Vilvert


          © INRA, EDP Sciences 2002