Fig. 4

Comparison of the power of different methods in scenarios with different sample sizes. a, b Heritability = 0.5; 0.001 ≤ MAF < 0.005; proportion of additive genetic variance explained by the QTL = 0.005; sample size in the test = 1000, 5000; with multiple rare variants simulated as QTL (a) and one rare variant simulated as QTL (b). c, d Heritability = 0.5; 0.001 ≤ MAF < 0.005; proportion of additive genetic variance explained by the QTL = 0.001; sample size in the test = 1000, 5000; with multiple rare variants simulated as QTL (c) and one rare variant simulated as QTL (d)