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Table 1 Scenarios used in the simulation

From: Comparison of gene-based rare variant association mapping methods for quantitative traits in a bovine population with complex familial relationships

Heritability

MAF

Proportion of additive genetic variance explained by the QTL

Sample size in the test

0.3

0.01 ≤ MAF < 0.02

0.005 ≤ MAF < 0.01

0.001 ≤ MAF < 0.005

MAF < 0.001

0.01

1000

0.5

0.01 ≤ MAF < 0.02

0.005 ≤ MAF < 0.01

0.001 ≤ MAF < 0.005

MAF < 0.001

0.01

1000

0.8

0.01 ≤ MAF < 0.02

0.005 ≤ MAF < 0.01

0.001 ≤ MAF < 0.005

MAF < 0.001

0.01

1000

0.5

0.001 ≤ MAF < 0.005

0.001; 0.005 or 0.01

1000

0.5

0.001 ≤ MAF < 0.005

0.001

1000; 5000

0.5

0.001 ≤ MAF < 0.005

0.005

1000; 5000