Deciphering mechanisms underlying the genetic variation of general production and liver quality traits in the overfed mule duck by pQTL analyses

Table 4 Functional enrichment analysis of canonical pathways between proteins with pQTL and the complete list of proteins

Ingenuity canonical pathways	Complete		pQTL		Proteins with pQTL in italic
Ingenuity canonical pathways	Regulated	Score^a	Regulated	Score^a	Proteins with pQTL in italic
Mitochondrial dysfunction	9/171 (5%)	7.22	7/171 (4%)	6.18	PDHA1, PRDX3, NDUFS1, SOD2, ATP5B, PARK7, GPX4, VDAC1, NDUFS3
Gluconeogenesis I	4/25 (16%)	5.40	4/25 (16%)	6.10	ENO1, PGAM1, ME1, MDH1
NRF2-mediated oxidative stress response	7/180 (4%)	4.85	6/180 (3%)	4.84	AKR1A1, SOD2, PRDX1, ACTB, VCP, CCT7, ACTG1
Glycolysis I	3/25 (12%)	3.76	3/25 (12%)	4.28	ENO1, TPI1, PGAM1
Acetyl-CoA biosynthesis I	3/7 (43%)	5.56	2/7 (29%)	3.76	PDHA1, DLAT, PDHB
LXR/RXR activation	5/121 (4%)	3.72	4/121 (3%)	3.36	TTR, ALB, APOA1, TF, FASN
FXR/RXR activation	5/126 (4%)	3.64	4/126 (3%)	3.29
Caveolar-mediated endocytosis signaling	3/71 (4%)	2.43	3/71 (4%)	2.93	ALB, ACTB, ACTG1
Acute phase response signaling	5/169 (3%)	3.06	4/169 (2%)	2.82	TTR, ALB, SOD2, APOA1, TF
TR/RXR activation	3/85 (4%)	2.21	3/85 (4%)	2.70	ENO1, FASN, ME1
Tryptophan degradation X	4/23 (17%)	5.55	2/23 (9%)	2.69	ALDH2, AKR1A1, ALDH9A1, ALDH7A1
Ethanol degradation II	4/35 (11%)	4.79	2/35 (6%)	2.33
Noradrenaline and adrenaline degradation	4/38 (11%)	4.65	2/38 (5%)	2.26
Clathrin-mediated Endocytosis signaling	5/185 (3%)	2.88	4/185 (2%)	2.67	ALB, APOA1, TF, ACTB, ACTG1

Only the top 14 canonical pathways are in this table
Proteins regulated by a pQTL are in italics; pQTL may concern only a sub-list of the complete list of proteins identified by proteomic analysis
^aScore corresponds to −log(P value)

ISSN: 1297-9686