Table 5 Functional enrichment analysis of biological functions between proteins with pQTL and the complete list of proteins
Diseases or function annotation (Ingenuity) | Complete | pQTL | ||||
|---|---|---|---|---|---|---|
P value | Number of molecules | Rank | P value | Number of molecules | Rank | |
Synthesis of purine nucleotide | 9.97E−10 | 11 | 6 | 5.69E−09 | 9 | 1 |
Metabolism of nucleic acid component or derivative | 7.89E−12 | 20 | 1 | 6.02E−09 | 14 | 2 |
Metabolism of dicarboxylic acid | 2.21E−07 | 5 | 16 | 2.91E−08 | 5 | 3 |
Metabolism of nucleotide | 2.07E−09 | 16 | 7 | 5.88E−08 | 12 | 4 |
Metabolism of hydrogen peroxide | 2.63E−10 | 10 | 2 | 1.03E−07 | 7 | 5 |
Cell viability | 6.29E−07 | 24 | 26 | 1.13E−07 | 20 | 6 |
Metabolism of nucleoside triphosphate | 2.3E−08 | 9 | 11 | 3.14E−07 | 7 | 7 |
Cell viability of tumor cell lines | 1.57E−05 | 16 | 41 | 3.45E−07 | 15 | 8 |
Catabolism of hydrogen peroxide | 3.02E−10 | 6 | 4 | 3.83E−07 | 4 | 9 |
Biosynthesis of purine ribonucleotide | 3.85E−07 | 7 | 21 | 6.28E−07 | 6 | 10 |
Synthesis of nucleotide | 6.13E−07 | 12 | 25 | 6.86E−07 | 10 | 11 |
Biosynthesis of nucleoside triphosphate | 5.98E−07 | 7 | 24 | 9.19E−07 | 6 | 12 |
Polymerization of protein | 6.77E−06 | 11 | 35 | 1.06E−06 | 10 | 13 |
Fatty acid metabolism | 1.46E−06 | 15 | 28 | 2.39E−06 | 12 | 14 |
Synthesis of acetyl-coenzyme A | 1.64E−07 | 4 | 13 | 5.15E−06 | 3 | 15 |