Table 4 The most important genomic regions and candidate genes derived from the window-based FST analyses of groups of breeds
Traits | Comparison | OCU:positiona | Candidate gene | FST | Previous studiesb |
|---|---|---|---|---|---|
Albino breeds | (Italian white + Giant White) vs all other breeds | 1:127563000–127668085 | TYR** | 0.52 | |
15:17113617–17196501 | EDNRA** | 0.58 | – | ||
Silver/graying of coat | (Italian Silver + Champagne d’Argent) vs all other breeds | Un513:25550–60684 | ADNP2** | 0.60 | – |
Un0329:192475–292759 | NFATC1 | 0.54 | – | ||
Checkered/spotted phenotype | (Checkered Giant + Rhinelander) vs all other breeds | 4:67503403–67541344 | KITLG | 0.51 | – |
Dwarf/small body size | (Coloured Dwarf + Dwarf Lop + Ermine) vs all other breeds | 2:8357629–8403513, 2:8404807–8620864 | LCORL**, NCAPG** | 0.50 | [19] |
18:7460895–8191494 | GRID1** | 0.59 | – | ||
Un0030:1681671–2068484 | NTRK2** | 0.54 | – | ||
Un0030:348764–635797 | FRMD3** | 0.57 | – | ||
7:115660028–115662696 | HOXD | 0.40* | [19] | ||
13:61054286–61261797 | COL11A1 | 0.42* | [19] | ||
Large body size | (Checkered Giant + Giant Grey + Giant White) vs all other breeds | 12:45671510–45793930; 12:45977386–46101862 | BMP5**, COL21A1** | 0.64 | – |
16:82626965–83800640, 16:53149315–53161403 | CDH13**, SLC30A10 | 0.57 | – | ||
2:39527266–39938880 | MSRA** | 0.53 | – | ||
4:44715759–44848250 | HMGA2** | 0.40* | [19] | ||
Meat production | Meat rabbit lines (Italian Silver + Italian Spotted + Italian White) vs all other breeds | 2:158326199–158338803 | MRPL33** | 0.57 | – |
15:58389801–59653895 | CCSER1** | 0.52 | – | ||
9:49249318–49360593 | PTPN2** | 0.51 | – | ||
Un0030:1681671–2068484 | NTRK2 | 0.49 | – |