The WUR0000125 PRRS resilience SNP had no apparent effect on pigs’ infectivity and susceptibility in a novel transmission trial

Table 3 Linear mixed model (LMM) for Shedder pig serum PRRSV-2 log₁₀TCID₅₀ at different sampling days for serum and nasal swab samples

Effect	Estimate	se	t	p-value
Serum
Initial pig weight (log₁₀ kg)	− 0.359	0.432	− 0.83	0.407
Shedder infection group (1 vs 2)	0.021	0.194	0.110	0.912
Shedder genotype (R− vs R+)	− 0.069	0.090	− 0.770	0.442
Day (relative to 7 dpc_S)
5 dpc_S	− 0.121	0.237	− 0.51	0.611
9 dpc_S	0.285	0.094	3.04	0.003
13 dpc_S	0.330	0.151	2.19	0.030
Day*Shedder infection group
Effect of shedder group (1 vs 2) at
5 dpc_S	0.893	0.331	2.70	0.008
7 dpc_S	0.021	0.194	0.11	0.912
9 dpc_S	− 0.219	0.130	− 1.69	0.093
13 dpc_S	− 0.311	0.100	− 3.10	0.002
Nasal swab
Initial pig weight (log₁₀ kg)	− 0.684	0.541	− 1.27	0.209
Shedder infection group (1 vs 2)	− 0.296	0.100	− 2.96	0.004
Shedder genotype (R− vs R+)	− 0.003	0.101	− 0.03	0.979
Day (relative to 7 dpc_S)^a
9 dpc_S	− 0.626	0.151	− 4.15	< 0.001
13 dpc_S	− 1.057	0.160	− 6.59	< 0.001

Estimate: Parameter estimate; se: standard error; t: t-value and 2 tailed p-value used in testing the null hypothesis that the coefficient/parameter is 0; R− and R+ : pigs with zero and one copy of the WUR resilience allele, respectively; dpc_S: Shedder pigs, days post contact from directly infected Inoculation pigs
^aNo nasal swabs were available at 5 dpc_S

ISSN: 1297-9686