The WUR0000125 PRRS resilience SNP had no apparent effect on pigs’ infectivity and susceptibility in a novel transmission trial

Table 5 Odds ratios and 95% CI for based on the generalised linear mixed model for whether Contact pigs were infected at Day 2 dpc_C, and infected by an R+ shedder at Day 10 dpc_C

Effect	Fixed effects model				Odds ratio
Effect	Estimate	se	t	p-value	OR^a	95% CI^b
Infected at Day 2 dpc_C
Intercept	– 6.069	2.68	– 2.27	0.033
Initial Contact pig weight (kg)	0.538	0.281	1.91	0.060	1.71	0.98–3.00
Shedder combination 1 vs 2	0.152	0.665	0.23	0.820	1.16	0.21–4.39
Contact pig genotype R− vs R+	0.346	0.669	0.52	0.606	1.41	0.373–5.36
Shedder nasal shedding^c	0.058	0.128	0.45	0.654	1.06	0.82–4.39
Infected by R+ shedder at Day 10 dpc_C^d
Intercept	0.480	1.20	0.40	0.694
Initial contact pig weight (kg)	− 0.168	0.183	–0.92	0.363	0.846	0.59–1.22
Shedder Infection group 1 vs 2	− 0.302	0.437	–0.69	0.492	0.739	0.309–1.77
Contact pig genotype R− vs R+	− 0.634	0.444	–1.43	0.158	0.531	0.219–1.288
R+ Shedder nasal shedding^e	0.108	0.061	1.76	0.083	1.114	0.986–1.26

Estimate: Parameter estimate; se: standard error; t: t-vaue and 2 tailed p-value used in testing the null hypothesis that the coefficient/parameter is 0; R− and R+ : pigs with zero and one copy of the WUR resilience allele, respectively; dpc_C, for Contact pigs, days post contact from directly infected Shedder pigs
^aOR: odds ratio = exp(Estimate);
^b95%CI for odds ratio = exp(Estimate ± 1.96*se)
^cTotal PRRSV-2 nasal shedding (sum log₁₀TCID₅₀) for all Shedder pigs in the room at 7 dpc_S
^dOn day 10 dpc_C 99% of the contact pigs were infected
^eTotal PRRSV-2 nasal shedding (sum log₁₀TCID₅₀) for R+ Shedder pigs in the room across all time points

ISSN: 1297-9686