The WUR0000125 PRRS resilience SNP had no apparent effect on pigs’ infectivity and susceptibility in a novel transmission trial

Table 6 Estimates from the linear mixed model of the effects on area under the curve (AUC_C) and Log₁₀TCID₅₀ of Contact pigs from serum samples

Effect	Estimate	se	t	p-value
Area under the curve (AUC_C)
Initial pig weight (kg)	0.755	0.582	1.30	0.199
Shedder combination 1 vs 2	−0.661	1.32	−0.50	0.617
Infected by R+ Shedder^a
No vs Yes	−3.37	1.39	−2.42	0.017
Contact genotype
R− vs R+	−1.21	1.30	−0.93	0.355
Shedder nasal shedding^b	−0.083	0.500	−0.55	0.583
Log₁₀TCID₅₀ (day 7 and 10 dpc_C)
Initial pig weight (kg)	0.045	0.054	0.83	0.409
Day (relative to 10 dpc_C) 7 dpc_C	−0.283	0.060	−4.71	< 0.001
Shedder combination 1 vs 2	0.014	0.115	0.130	0.900
Infected by R+ Shedder^a
No vs Yes	−0.260	0.121	−2.14	0.034
Contact genotype
R− vs R+	−0.042	0.113	−0.37	0.712
Shedder nasal shedding^b	−0.011	0.013	−0.850	0.399

Estimate: Parameter estimate; se: standard error; t: t-value and 2 tailed p-value used in testing the null hypothesis that the coefficient/parameter is 0; R– and R+ : pigs with zero and one copy of the WUR resilience allele, respectively; dpc_C, for Contact pigs, days post contact from directly infected Shedder pigs
^aBoth R+ and R− Shedder pigs genotypes were detected in three pigs. These pigs were removed from the analysis along with the single uninfected contact pig
^bTotal PRRSV-2 nasal shedding (sum log₁₀TCID₅₀) for Shedder pigs in the room across all time points

ISSN: 1297-9686